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Genetic association tests based on ranks (GATOR) for quantitative traits with and without censoring.

Publication ,  Journal Article
Allen, AS; Martin, ER; Qin, X; Li, Y-J
Published in: Genet Epidemiol
April 2006

Linkage disequilibrium mapping of quantitative traits is a powerful method for dissecting the genetic etiology of complex phenotypes. Quantitative traits, however, often exhibit characteristics that make their use problematic. For example, the distribution of the trait may be censored, highly skewed, or contaminated with outlying values. We propose here a rank-based framework for deriving tests of gene and trait association that explicitly take censoring into account and are insensitive to skewness and outlying values. Standard methods for mapping quantitative traits do not take these characteristics into account, which leads to the discarding of valuable information or their improper application. We show how this framework can be applied in nuclear families and discuss its implementation in general pedigrees. The power and efficacy of the approach is illustrated through a series of simulation experiments in which the approach is compared to existing methods.

Duke Scholars

Published In

Genet Epidemiol

DOI

ISSN

0741-0395

Publication Date

April 2006

Volume

30

Issue

3

Start / End Page

248 / 258

Location

United States

Related Subject Headings

  • Phenotype
  • Models, Theoretical
  • Models, Genetic
  • Humans
  • Genotype
  • Family
  • Epidemiology
  • Age of Onset
  • 4202 Epidemiology
  • 3105 Genetics
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Allen, A. S., Martin, E. R., Qin, X., & Li, Y.-J. (2006). Genetic association tests based on ranks (GATOR) for quantitative traits with and without censoring. Genet Epidemiol, 30(3), 248–258. https://doi.org/10.1002/gepi.20141
Allen, Andrew S., Eden R. Martin, Xuejun Qin, and Yi-Ju Li. “Genetic association tests based on ranks (GATOR) for quantitative traits with and without censoring.Genet Epidemiol 30, no. 3 (April 2006): 248–58. https://doi.org/10.1002/gepi.20141.
Allen AS, Martin ER, Qin X, Li Y-J. Genetic association tests based on ranks (GATOR) for quantitative traits with and without censoring. Genet Epidemiol. 2006 Apr;30(3):248–58.
Allen, Andrew S., et al. “Genetic association tests based on ranks (GATOR) for quantitative traits with and without censoring.Genet Epidemiol, vol. 30, no. 3, Apr. 2006, pp. 248–58. Pubmed, doi:10.1002/gepi.20141.
Allen AS, Martin ER, Qin X, Li Y-J. Genetic association tests based on ranks (GATOR) for quantitative traits with and without censoring. Genet Epidemiol. 2006 Apr;30(3):248–258.
Journal cover image

Published In

Genet Epidemiol

DOI

ISSN

0741-0395

Publication Date

April 2006

Volume

30

Issue

3

Start / End Page

248 / 258

Location

United States

Related Subject Headings

  • Phenotype
  • Models, Theoretical
  • Models, Genetic
  • Humans
  • Genotype
  • Family
  • Epidemiology
  • Age of Onset
  • 4202 Epidemiology
  • 3105 Genetics