APOE genotype is a risk factor for neuropathy severity in diabetic patients.
Publication
, Journal Article
Bedlack, RS; Edelman, D; Gibbs, JW; Kelling, D; Strittmatter, W; Saunders, AM; Morgenlander, J
Published in: Neurology
March 25, 2003
This cross-sectional study tested the hypothesis that APOE genotype is a risk factor for diabetic neuropathy severity. A model with age, duration of diabetes, and APOE genotype was found to predict (p = 0.0083) severity on the Neuropathy Impairment Score in the Lower Limbs (NISLL). Considering genotype alone, patients with APOE 3/4 and 4/4 genotypes had 3 more NISLL points than patients with other genotypes. This impact on severity is equivalent to having 15 extra years of age or diabetes duration.
Duke Scholars
Published In
Neurology
DOI
EISSN
1526-632X
Publication Date
March 25, 2003
Volume
60
Issue
6
Start / End Page
1022 / 1024
Location
United States
Related Subject Headings
- Severity of Illness Index
- Risk Factors
- Neurology & Neurosurgery
- Middle Aged
- Male
- Humans
- Genotype
- Genetic Predisposition to Disease
- Female
- Diabetic Neuropathies
Citation
APA
Chicago
ICMJE
MLA
NLM
Bedlack, R. S., Edelman, D., Gibbs, J. W., Kelling, D., Strittmatter, W., Saunders, A. M., & Morgenlander, J. (2003). APOE genotype is a risk factor for neuropathy severity in diabetic patients. Neurology, 60(6), 1022–1024. https://doi.org/10.1212/01.wnl.0000056689.50682.94
Bedlack, R. S., D. Edelman, J. W. Gibbs, D. Kelling, W. Strittmatter, A. M. Saunders, and J. Morgenlander. “APOE genotype is a risk factor for neuropathy severity in diabetic patients.” Neurology 60, no. 6 (March 25, 2003): 1022–24. https://doi.org/10.1212/01.wnl.0000056689.50682.94.
Bedlack RS, Edelman D, Gibbs JW, Kelling D, Strittmatter W, Saunders AM, et al. APOE genotype is a risk factor for neuropathy severity in diabetic patients. Neurology. 2003 Mar 25;60(6):1022–4.
Bedlack, R. S., et al. “APOE genotype is a risk factor for neuropathy severity in diabetic patients.” Neurology, vol. 60, no. 6, Mar. 2003, pp. 1022–24. Pubmed, doi:10.1212/01.wnl.0000056689.50682.94.
Bedlack RS, Edelman D, Gibbs JW, Kelling D, Strittmatter W, Saunders AM, Morgenlander J. APOE genotype is a risk factor for neuropathy severity in diabetic patients. Neurology. 2003 Mar 25;60(6):1022–1024.
Published In
Neurology
DOI
EISSN
1526-632X
Publication Date
March 25, 2003
Volume
60
Issue
6
Start / End Page
1022 / 1024
Location
United States
Related Subject Headings
- Severity of Illness Index
- Risk Factors
- Neurology & Neurosurgery
- Middle Aged
- Male
- Humans
- Genotype
- Genetic Predisposition to Disease
- Female
- Diabetic Neuropathies