Correction of chronic granulomatous disease after second unrelated-donor umbilical cord blood transplantation.
Publication
, Journal Article
Parikh, SH; Szabolcs, P; Prasad, VK; Lakshminarayanan, S; Martin, PL; Driscoll, TA; Kurtzberg, J
Published in: Pediatr Blood Cancer
December 2007
Allogeneic hematopoietic stem cell transplantation (HSCT) is curative for chronic granulomatous disease (CGD), but many patients lack a suitably matched related donor. We report successful outcomes after mismatched, unrelated-donor umbilical cord blood transplantation (uUCBT) in two boys with X-linked CGD. Both patients experienced autologous recovery after first transplants, required second transplants to achieve durable donor engraftment, and are alive 27 and 15 months post-transplant. Both had invasive fungal disease and received granulocyte transfusions. In conclusion, uUCBT is effective in children with CGD, but immunosuppression in the conditioning regimen may need to be increased to decrease the risk of graft rejection.
Duke Scholars
Published In
Pediatr Blood Cancer
DOI
ISSN
1545-5009
Publication Date
December 2007
Volume
49
Issue
7
Start / End Page
982 / 984
Location
United States
Related Subject Headings
- Treatment Outcome
- Transplantation, Homologous
- Risk Factors
- Oncology & Carcinogenesis
- Male
- Infant
- Humans
- Granulomatous Disease, Chronic
- Graft vs Host Disease
- Follow-Up Studies
Citation
APA
Chicago
ICMJE
MLA
NLM
Parikh, S. H., Szabolcs, P., Prasad, V. K., Lakshminarayanan, S., Martin, P. L., Driscoll, T. A., & Kurtzberg, J. (2007). Correction of chronic granulomatous disease after second unrelated-donor umbilical cord blood transplantation. Pediatr Blood Cancer, 49(7), 982–984. https://doi.org/10.1002/pbc.21365
Parikh, Suhag H., Paul Szabolcs, Vinod K. Prasad, Sonali Lakshminarayanan, Paul L. Martin, Timothy A. Driscoll, and Joanne Kurtzberg. “Correction of chronic granulomatous disease after second unrelated-donor umbilical cord blood transplantation.” Pediatr Blood Cancer 49, no. 7 (December 2007): 982–84. https://doi.org/10.1002/pbc.21365.
Parikh SH, Szabolcs P, Prasad VK, Lakshminarayanan S, Martin PL, Driscoll TA, et al. Correction of chronic granulomatous disease after second unrelated-donor umbilical cord blood transplantation. Pediatr Blood Cancer. 2007 Dec;49(7):982–4.
Parikh, Suhag H., et al. “Correction of chronic granulomatous disease after second unrelated-donor umbilical cord blood transplantation.” Pediatr Blood Cancer, vol. 49, no. 7, Dec. 2007, pp. 982–84. Pubmed, doi:10.1002/pbc.21365.
Parikh SH, Szabolcs P, Prasad VK, Lakshminarayanan S, Martin PL, Driscoll TA, Kurtzberg J. Correction of chronic granulomatous disease after second unrelated-donor umbilical cord blood transplantation. Pediatr Blood Cancer. 2007 Dec;49(7):982–984.
Published In
Pediatr Blood Cancer
DOI
ISSN
1545-5009
Publication Date
December 2007
Volume
49
Issue
7
Start / End Page
982 / 984
Location
United States
Related Subject Headings
- Treatment Outcome
- Transplantation, Homologous
- Risk Factors
- Oncology & Carcinogenesis
- Male
- Infant
- Humans
- Granulomatous Disease, Chronic
- Graft vs Host Disease
- Follow-Up Studies