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Analgesic drug use and risk of ovarian cancer.

Publication ,  Journal Article
Schildkraut, JM; Moorman, PG; Halabi, S; Calingaert, B; Marks, JR; Berchuck, A
Published in: Epidemiology
January 2006

BACKGROUND: Previous epidemiologic research suggests that analgesic use may reduce the risk of ovarian cancer, although results are not consistent. METHODS: In a population-based, case-control study, we analyzed data from 586 ovarian cancer cases and 627 matched controls in North Carolina for the relationship between analgesic use and ovarian cancer risk. Logistic regression analysis was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) while adjusting for potential confounders. RESULTS: Use of any nonsteroidal antiinflammatory drugs, including aspirin, within 5 years of diagnosis/interview was found to be associated with a reduction in the risk of ovarian cancer (adjusted OR = 0.72; 95% CI = 0.56-0.92). For use of acetaminophen, the OR was 0.78 (95% CI = 0.56-1.08). CONCLUSIONS: These data support an inverse relationship between the use of both nonsteroidal antiinflammatory drugs and acetaminophen and the risk of ovarian cancer.

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Published In

Epidemiology

DOI

ISSN

1044-3983

Publication Date

January 2006

Volume

17

Issue

1

Start / End Page

104 / 107

Location

United States

Related Subject Headings

  • Risk Factors
  • Ovarian Neoplasms
  • Odds Ratio
  • North Carolina
  • Middle Aged
  • Humans
  • Female
  • Epidemiology
  • Confounding Factors, Epidemiologic
  • Case-Control Studies
 

Citation

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Schildkraut, J. M., Moorman, P. G., Halabi, S., Calingaert, B., Marks, J. R., & Berchuck, A. (2006). Analgesic drug use and risk of ovarian cancer. Epidemiology, 17(1), 104–107. https://doi.org/10.1097/01.ede.0000190538.55645.f8
Schildkraut, Joellen M., Patricia G. Moorman, Susan Halabi, Brian Calingaert, Jeffrey R. Marks, and Andrew Berchuck. “Analgesic drug use and risk of ovarian cancer.Epidemiology 17, no. 1 (January 2006): 104–7. https://doi.org/10.1097/01.ede.0000190538.55645.f8.
Schildkraut JM, Moorman PG, Halabi S, Calingaert B, Marks JR, Berchuck A. Analgesic drug use and risk of ovarian cancer. Epidemiology. 2006 Jan;17(1):104–7.
Schildkraut, Joellen M., et al. “Analgesic drug use and risk of ovarian cancer.Epidemiology, vol. 17, no. 1, Jan. 2006, pp. 104–07. Pubmed, doi:10.1097/01.ede.0000190538.55645.f8.
Schildkraut JM, Moorman PG, Halabi S, Calingaert B, Marks JR, Berchuck A. Analgesic drug use and risk of ovarian cancer. Epidemiology. 2006 Jan;17(1):104–107.

Published In

Epidemiology

DOI

ISSN

1044-3983

Publication Date

January 2006

Volume

17

Issue

1

Start / End Page

104 / 107

Location

United States

Related Subject Headings

  • Risk Factors
  • Ovarian Neoplasms
  • Odds Ratio
  • North Carolina
  • Middle Aged
  • Humans
  • Female
  • Epidemiology
  • Confounding Factors, Epidemiologic
  • Case-Control Studies