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Effects of acute and chronic inflammation on B-cell development and differentiation.

Publication ,  Journal Article
Cain, D; Kondo, M; Chen, H; Kelsoe, G
Published in: J Invest Dermatol
February 2009

Recently, our understanding of hematopoiesis and the development of the immune system has fundamentally changed, leading to significant discoveries with important clinical relevance. Hematopoiesis, once described in terms of irreversible and discrete developmental branch points, is now understood to exist as a collection of alternative developmental pathways capable of generating functionally identical progeny. Developmental commitment to a particular blood-cell lineage is gradually acquired and reflects both cell intrinsic and extrinsic signals. Chief among the extrinsic factors are the environmental cues of hematopoietic microenvironments that comprise specific "developmental niches" that support hematopoietic stem and progenitor cells. Most of this new understanding comes from the study of normal, steady-state hematopoiesis, but there is ample reason to expect that special developmental and/or differentiative mechanisms operate in response to inflammation. For example, both stem and progenitor cells are now known to express Toll-like receptors that can influence hematopoietic cell fates in response to microbial products. Likewise, proinflammatory cytokines mobilize hematopoietic stem cells to peripheral tissues. In this Perspective, we review inflammation's effects on central and extramedullary B lymphopoiesis and discuss the potential consequences of peripheral B-cell development in the context of systemic autoimmune diseases.

Duke Scholars

Published In

J Invest Dermatol

DOI

EISSN

1523-1747

Publication Date

February 2009

Volume

129

Issue

2

Start / End Page

266 / 277

Location

United States

Related Subject Headings

  • Inflammation
  • Humans
  • Hematopoiesis
  • Dermatology & Venereal Diseases
  • Chronic Disease
  • Cell Differentiation
  • B-Lymphocytes
  • Autoimmune Diseases
  • Animals
  • Acute Disease
 

Citation

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ICMJE
MLA
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Cain, D., Kondo, M., Chen, H., & Kelsoe, G. (2009). Effects of acute and chronic inflammation on B-cell development and differentiation. J Invest Dermatol, 129(2), 266–277. https://doi.org/10.1038/jid.2008.286
Cain, Derek, Motonari Kondo, Huaiyong Chen, and Garnett Kelsoe. “Effects of acute and chronic inflammation on B-cell development and differentiation.J Invest Dermatol 129, no. 2 (February 2009): 266–77. https://doi.org/10.1038/jid.2008.286.
Cain D, Kondo M, Chen H, Kelsoe G. Effects of acute and chronic inflammation on B-cell development and differentiation. J Invest Dermatol. 2009 Feb;129(2):266–77.
Cain, Derek, et al. “Effects of acute and chronic inflammation on B-cell development and differentiation.J Invest Dermatol, vol. 129, no. 2, Feb. 2009, pp. 266–77. Pubmed, doi:10.1038/jid.2008.286.
Cain D, Kondo M, Chen H, Kelsoe G. Effects of acute and chronic inflammation on B-cell development and differentiation. J Invest Dermatol. 2009 Feb;129(2):266–277.
Journal cover image

Published In

J Invest Dermatol

DOI

EISSN

1523-1747

Publication Date

February 2009

Volume

129

Issue

2

Start / End Page

266 / 277

Location

United States

Related Subject Headings

  • Inflammation
  • Humans
  • Hematopoiesis
  • Dermatology & Venereal Diseases
  • Chronic Disease
  • Cell Differentiation
  • B-Lymphocytes
  • Autoimmune Diseases
  • Animals
  • Acute Disease