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The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium.

Publication ,  Journal Article
Rawlins, EL; Okubo, T; Xue, Y; Brass, DM; Auten, RL; Hasegawa, H; Wang, F; Hogan, BLM
Published in: Cell Stem Cell
June 5, 2009

To directly test the contribution of Scgb1a1(+) Clara cells to postnatal growth, homeostasis, and repair of lung epithelium, we generated a Scgb1a1-CreER "knockin" mouse for lineage-tracing these cells. Under all conditions tested, the majority of Clara cells in the bronchioles both self-renews and generates ciliated cells. In the trachea, Clara cells give rise to ciliated cells but do not self-renew extensively. Nevertheless, they can contribute to tracheal repair. In the postnatal mouse lung, it has been proposed that bronchioalveolar stem cells (BASCs) which coexpress Scgb1a1 (Secretoglobin1a1) and SftpC (Surfactant Protein C), contribute descendants to both bronchioles and alveoli. The putative BASCs were lineage labeled in our studies. However, we find no evidence for the function of a special BASC population during postnatal growth, adult homeostasis, or repair. Rather, our results support a model in which the trachea, bronchioles, and alveoli are maintained by distinct populations of epithelial progenitor cells.

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Published In

Cell Stem Cell

DOI

EISSN

1875-9777

Publication Date

June 5, 2009

Volume

4

Issue

6

Start / End Page

525 / 534

Location

United States

Related Subject Headings

  • Wound Healing
  • Uteroglobin
  • Trachea
  • Stem Cells
  • Respiratory System
  • Regeneration
  • Pulmonary Alveoli
  • Mice, Transgenic
  • Mice
  • Lung
 

Citation

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MLA
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Rawlins, E. L., Okubo, T., Xue, Y., Brass, D. M., Auten, R. L., Hasegawa, H., … Hogan, B. L. M. (2009). The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium. Cell Stem Cell, 4(6), 525–534. https://doi.org/10.1016/j.stem.2009.04.002
Rawlins, Emma L., Tadashi Okubo, Yan Xue, David M. Brass, Richard L. Auten, Hiroshi Hasegawa, Fan Wang, and Brigid L. M. Hogan. “The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium.Cell Stem Cell 4, no. 6 (June 2009): 525–34. https://doi.org/10.1016/j.stem.2009.04.002.
Rawlins EL, Okubo T, Xue Y, Brass DM, Auten RL, Hasegawa H, et al. The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium. Cell stem cell. 2009 Jun;4(6):525–34.
Rawlins, Emma L., et al. “The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium.Cell Stem Cell, vol. 4, no. 6, June 2009, pp. 525–34. Epmc, doi:10.1016/j.stem.2009.04.002.
Rawlins EL, Okubo T, Xue Y, Brass DM, Auten RL, Hasegawa H, Wang F, Hogan BLM. The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium. Cell stem cell. 2009 Jun;4(6):525–534.
Journal cover image

Published In

Cell Stem Cell

DOI

EISSN

1875-9777

Publication Date

June 5, 2009

Volume

4

Issue

6

Start / End Page

525 / 534

Location

United States

Related Subject Headings

  • Wound Healing
  • Uteroglobin
  • Trachea
  • Stem Cells
  • Respiratory System
  • Regeneration
  • Pulmonary Alveoli
  • Mice, Transgenic
  • Mice
  • Lung