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Time course of carbamazepine autoinduction. The VA Cooperative Study No.118 Group.

Publication ,  Journal Article
Mikati, MA; Browne, TR; Collins, JF
Published in: Neurology
April 1989

We sequentially determined carbamazepine clearance values in 17 patients at the end of weeks 1, 2, 4, 8, and 12 of monotherapy. There were no significant differences among these clearance values. In 11 of 17 patients, week 1 clearance accurately predicted week 12 carbamazepine serum concentration (within +/- 33%). Our data indicate that carbamazepine autoinduction was completed within the first 1 or 2 weeks of monotherapy. Serum concentration values obtained after 1 week of monotherapy, using our dosing regimen, can be used to predict directly the dosing rate needed to obtain a specific serum concentration in most patients.

Duke Scholars

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

April 1989

Volume

39

Issue

4

Start / End Page

592 / 594

Location

United States

Related Subject Headings

  • Time Factors
  • Seizures
  • Neurology & Neurosurgery
  • Middle Aged
  • Metabolic Clearance Rate
  • Male
  • Humans
  • Female
  • Carbamazepine
  • Adult
 

Citation

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Chicago
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MLA
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Mikati, M. A., Browne, T. R., & Collins, J. F. (1989). Time course of carbamazepine autoinduction. The VA Cooperative Study No.118 Group. Neurology, 39(4), 592–594. https://doi.org/10.1212/wnl.39.4.592
Mikati, M. A., T. R. Browne, and J. F. Collins. “Time course of carbamazepine autoinduction. The VA Cooperative Study No.118 Group.Neurology 39, no. 4 (April 1989): 592–94. https://doi.org/10.1212/wnl.39.4.592.
Mikati MA, Browne TR, Collins JF. Time course of carbamazepine autoinduction. The VA Cooperative Study No.118 Group. Neurology. 1989 Apr;39(4):592–4.
Mikati, M. A., et al. “Time course of carbamazepine autoinduction. The VA Cooperative Study No.118 Group.Neurology, vol. 39, no. 4, Apr. 1989, pp. 592–94. Pubmed, doi:10.1212/wnl.39.4.592.
Mikati MA, Browne TR, Collins JF. Time course of carbamazepine autoinduction. The VA Cooperative Study No.118 Group. Neurology. 1989 Apr;39(4):592–594.

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

April 1989

Volume

39

Issue

4

Start / End Page

592 / 594

Location

United States

Related Subject Headings

  • Time Factors
  • Seizures
  • Neurology & Neurosurgery
  • Middle Aged
  • Metabolic Clearance Rate
  • Male
  • Humans
  • Female
  • Carbamazepine
  • Adult