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Analysis of total uncertainty in spectral peak measurements for plasmonic nanoparticle-based biosensors.

Publication ,  Journal Article
Curry, A; Nusz, G; Chilkoti, A; Wax, A
Published in: Applied optics
April 2007

One goal of recent research on plasmonic nanoparticle-based sensors is maximizing nanoparticle sensitivity or shift of resonance peak wavelength per refractive index change. Equally important is a measurement system's peak location uncertainty or shift resolution. We provide systematic analyses and discuss optimization of factors that determine peak location uncertainty, reporting values as low as 0.3 nm for the presented scheme. This type of analysis is important, in part, because it provides a means of evaluating detection thresholds for biosensor applications such as analyte binding. We estimate thresholds of 310 streptavidin molecules for the presented scheme and 20 molecules with system improvements.

Duke Scholars

Published In

Applied optics

DOI

EISSN

1539-4522

ISSN

1559-128X

Publication Date

April 2007

Volume

46

Issue

10

Start / End Page

1931 / 1939

Related Subject Headings

  • Surface Plasmon Resonance
  • Spectrum Analysis
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Optics
  • Nanoparticles
  • Equipment Failure Analysis
  • Biosensing Techniques
  • 5102 Atomic, molecular and optical physics
  • 4008 Electrical engineering
 

Citation

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ICMJE
MLA
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Curry, A., Nusz, G., Chilkoti, A., & Wax, A. (2007). Analysis of total uncertainty in spectral peak measurements for plasmonic nanoparticle-based biosensors. Applied Optics, 46(10), 1931–1939. https://doi.org/10.1364/ao.46.001931
Curry, Adam, Gregory Nusz, Ashutosh Chilkoti, and Adam Wax. “Analysis of total uncertainty in spectral peak measurements for plasmonic nanoparticle-based biosensors.Applied Optics 46, no. 10 (April 2007): 1931–39. https://doi.org/10.1364/ao.46.001931.
Curry A, Nusz G, Chilkoti A, Wax A. Analysis of total uncertainty in spectral peak measurements for plasmonic nanoparticle-based biosensors. Applied optics. 2007 Apr;46(10):1931–9.
Curry, Adam, et al. “Analysis of total uncertainty in spectral peak measurements for plasmonic nanoparticle-based biosensors.Applied Optics, vol. 46, no. 10, Apr. 2007, pp. 1931–39. Epmc, doi:10.1364/ao.46.001931.
Curry A, Nusz G, Chilkoti A, Wax A. Analysis of total uncertainty in spectral peak measurements for plasmonic nanoparticle-based biosensors. Applied optics. 2007 Apr;46(10):1931–1939.

Published In

Applied optics

DOI

EISSN

1539-4522

ISSN

1559-128X

Publication Date

April 2007

Volume

46

Issue

10

Start / End Page

1931 / 1939

Related Subject Headings

  • Surface Plasmon Resonance
  • Spectrum Analysis
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Optics
  • Nanoparticles
  • Equipment Failure Analysis
  • Biosensing Techniques
  • 5102 Atomic, molecular and optical physics
  • 4008 Electrical engineering