
Preoperative radiotherapy and bevacizumab for angiosarcoma of the head and neck: two case studies.
BACKGROUND: Angiosarcoma of the face is a vascular tumor with poor local control and short median survival despite standard treatment. Bevacizumab is a humanized monoclonal antibody to vascular endothelial growth factor (VEGF), which can inhibit tumor growth. It is synergistic with radiotherapy in gastrointestinal malignancies. Given the vascular nature of angiosarcoma and the need for better treatment of this disease, we investigated the concurrent use of bevacizumab with preoperative radiotherapy for head and neck angiosarcoma. METHODS: Two patients diagnosed with angiosarcoma of the nose were treated preoperatively with bevacizumab (5-10 mg/kg) and concurrent radiotherapy (50 Gy), followed by resection of the tumor bed. RESULTS: Both patients had a complete pathologic response with no residual disease. Neither has developed recurrence, with follow-up of 8.5 months and 2.1 years. CONCLUSIONS: The neoadjuvant combination of bevacizumab and radiation therapy is promising and should be further studied in the setting of vascular malignancies.
Duke Scholars
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Radiotherapy Dosage
- Otorhinolaryngology
- Neoadjuvant Therapy
- Middle Aged
- Male
- Humans
- Hemangiosarcoma
- Head and Neck Neoplasms
- Combined Modality Therapy
- Chemotherapy, Adjuvant
Citation

Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Radiotherapy Dosage
- Otorhinolaryngology
- Neoadjuvant Therapy
- Middle Aged
- Male
- Humans
- Hemangiosarcoma
- Head and Neck Neoplasms
- Combined Modality Therapy
- Chemotherapy, Adjuvant