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Apolipoprotein E protects against NMDA excitotoxicity.

Publication ,  Journal Article
Aono, M; Lee, Y; Grant, ER; Zivin, RA; Pearlstein, RD; Warner, DS; Bennett, ER; Laskowitz, DT
Published in: Neurobiol Dis
October 2002

Preclinical and clinical evidence implicates a role for endogenous apolipoprotein E in modifying the response of the brain to focal and global ischemia. To investigate whether apoE modulates the neuronal response to glutamate excitotoxicity, we exposed primary neuronal glial cultures and a neuronal cell line to biologically relevant concentrations of apolipoprotein E prior to NMDA exposure. In both of these paradigms, apolipoprotein E exerted partial protective effects. At neuroprotective concentrations, however, apolipoprotein E failed to block NMDA-induced calcium influx to the same magnitude as the NMDA receptor antagonist MK-801. These results suggest that one mechanism by which apolipoprotein E modifies the central nervous system response to ischemia may be by reducing glutamate-induced excitotoxicity.

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Published In

Neurobiol Dis

DOI

ISSN

0969-9961

Publication Date

October 2002

Volume

11

Issue

1

Start / End Page

214 / 220

Location

United States

Related Subject Headings

  • Rats, Sprague-Dawley
  • Rats
  • Neurotoxins
  • Neuroprotective Agents
  • Neurons
  • Neurology & Neurosurgery
  • Neuroglia
  • N-Methylaspartate
  • Excitatory Amino Acid Agonists
  • Cells, Cultured
 

Citation

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Aono, M., Lee, Y., Grant, E. R., Zivin, R. A., Pearlstein, R. D., Warner, D. S., … Laskowitz, D. T. (2002). Apolipoprotein E protects against NMDA excitotoxicity. Neurobiol Dis, 11(1), 214–220. https://doi.org/10.1006/nbdi.2002.0541
Aono, Mitsuo, Yoonki Lee, Elfrida R. Grant, Robert A. Zivin, Robert D. Pearlstein, David S. Warner, Ellen R. Bennett, and Daniel T. Laskowitz. “Apolipoprotein E protects against NMDA excitotoxicity.Neurobiol Dis 11, no. 1 (October 2002): 214–20. https://doi.org/10.1006/nbdi.2002.0541.
Aono M, Lee Y, Grant ER, Zivin RA, Pearlstein RD, Warner DS, et al. Apolipoprotein E protects against NMDA excitotoxicity. Neurobiol Dis. 2002 Oct;11(1):214–20.
Aono, Mitsuo, et al. “Apolipoprotein E protects against NMDA excitotoxicity.Neurobiol Dis, vol. 11, no. 1, Oct. 2002, pp. 214–20. Pubmed, doi:10.1006/nbdi.2002.0541.
Aono M, Lee Y, Grant ER, Zivin RA, Pearlstein RD, Warner DS, Bennett ER, Laskowitz DT. Apolipoprotein E protects against NMDA excitotoxicity. Neurobiol Dis. 2002 Oct;11(1):214–220.
Journal cover image

Published In

Neurobiol Dis

DOI

ISSN

0969-9961

Publication Date

October 2002

Volume

11

Issue

1

Start / End Page

214 / 220

Location

United States

Related Subject Headings

  • Rats, Sprague-Dawley
  • Rats
  • Neurotoxins
  • Neuroprotective Agents
  • Neurons
  • Neurology & Neurosurgery
  • Neuroglia
  • N-Methylaspartate
  • Excitatory Amino Acid Agonists
  • Cells, Cultured