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Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension.

Publication ,  Journal Article
Polanczyk, G; Caspi, A; Williams, B; Price, TS; Danese, A; Sugden, K; Uher, R; Poulton, R; Moffitt, TE
Published in: Archives of general psychiatry
September 2009

A previous study reported a gene x environment interaction in which a haplotype in the corticotropin-releasing hormone receptor 1 gene (CRHR1) was associated with protection against adult depressive symptoms in individuals who were maltreated as children (as assessed by the Childhood Trauma Questionnaire [CTQ]).To replicate the interaction between childhood maltreatment and a TAT haplotype formed by rs7209436, rs110402, and rs242924 in CRHR1, predicting adult depression.Two prospective longitudinal cohort studies.England and New Zealand.Participants in the first sample were women in the E-Risk Study (N = 1116), followed up to age 40 years with 96% retention. Participants in the second sample were men and women in the Dunedin Study (N = 1037), followed up to age 32 years with 96% retention. Main Outcome Measure Research diagnoses of past-year and recurrent major depressive disorder.In the E-Risk Study, the TAT haplotype was associated with a significant protective effect. In this effect, women who reported childhood maltreatment on the CTQ were protected against depression. In the Dunedin Study, which used a different type of measure of maltreatment, this finding was not replicated.A haplotype in CRHR1 has been suggested to exert a protective effect against adult depression among research participants who reported maltreatment on the CTQ, a measure that elicits emotional memories. This suggests the hypothesis that CRHR1's protective effect may relate to its function in the consolidation of memories of emotionally arousing experiences.

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Published In

Archives of general psychiatry

DOI

EISSN

1538-3636

ISSN

0003-990X

Publication Date

September 2009

Volume

66

Issue

9

Start / End Page

978 / 985

Related Subject Headings

  • Surveys and Questionnaires
  • Receptors, Corticotropin-Releasing Hormone
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Polymorphism, Single Nucleotide
  • Polymorphism, Genetic
  • Middle Aged
  • Male
  • Life Change Events
  • Humans
 

Citation

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Polanczyk, G., Caspi, A., Williams, B., Price, T. S., Danese, A., Sugden, K., … Moffitt, T. E. (2009). Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension. Archives of General Psychiatry, 66(9), 978–985. https://doi.org/10.1001/archgenpsychiatry.2009.114
Polanczyk, Guilherme, Avshalom Caspi, Benjamin Williams, Thomas S. Price, Andrea Danese, Karen Sugden, Rudolf Uher, Richie Poulton, and Terrie E. Moffitt. “Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension.Archives of General Psychiatry 66, no. 9 (September 2009): 978–85. https://doi.org/10.1001/archgenpsychiatry.2009.114.
Polanczyk G, Caspi A, Williams B, Price TS, Danese A, Sugden K, et al. Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension. Archives of general psychiatry. 2009 Sep;66(9):978–85.
Polanczyk, Guilherme, et al. “Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension.Archives of General Psychiatry, vol. 66, no. 9, Sept. 2009, pp. 978–85. Epmc, doi:10.1001/archgenpsychiatry.2009.114.
Polanczyk G, Caspi A, Williams B, Price TS, Danese A, Sugden K, Uher R, Poulton R, Moffitt TE. Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension. Archives of general psychiatry. 2009 Sep;66(9):978–985.

Published In

Archives of general psychiatry

DOI

EISSN

1538-3636

ISSN

0003-990X

Publication Date

September 2009

Volume

66

Issue

9

Start / End Page

978 / 985

Related Subject Headings

  • Surveys and Questionnaires
  • Receptors, Corticotropin-Releasing Hormone
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Polymorphism, Single Nucleotide
  • Polymorphism, Genetic
  • Middle Aged
  • Male
  • Life Change Events
  • Humans