Exploring type I angiotensin (AT1) receptor functions through gene targeting.
Publication
, Journal Article
Crowley, SD; Tharaux, P-L; Audoly, LP; Coffman, TM
Published in: Acta Physiol Scand
August 2004
The renin-angiotensin system (RAS) modulates a diverse set of physiological processes including development, blood pressure, renal function and inflammation. The principal effector molecule of this system, angiotensin II, mediates most of these actions. The classically recognized functions of the RAS are triggered via the type 1 (AT(1)) class of angiotensin receptors. Pharmacological blockade of the AT(1) receptor lowers blood pressure and slows the progression of cardiovascular and renal diseases. Gene-targeting technology provides an experimental approach for precisely dissecting the physiological functions of the RAS. Here, we review how gene-targeting experiments have elucidated AT(1) receptor functions.
Duke Scholars
Published In
Acta Physiol Scand
DOI
ISSN
0001-6772
Publication Date
August 2004
Volume
181
Issue
4
Start / End Page
561 / 570
Location
England
Related Subject Headings
- Renin-Angiotensin System
- Receptor, Angiotensin, Type 1
- Physiology
- Mice, Transgenic
- Mice
- Kidney
- Hypertension
- Humans
- Gene Targeting
- Disease Models, Animal
Citation
APA
Chicago
ICMJE
MLA
NLM
Crowley, S. D., Tharaux, P.-L., Audoly, L. P., & Coffman, T. M. (2004). Exploring type I angiotensin (AT1) receptor functions through gene targeting. Acta Physiol Scand, 181(4), 561–570. https://doi.org/10.1111/j.1365-201X.2004.01331.x
Crowley, S. D., P. -. L. Tharaux, L. P. Audoly, and T. M. Coffman. “Exploring type I angiotensin (AT1) receptor functions through gene targeting.” Acta Physiol Scand 181, no. 4 (August 2004): 561–70. https://doi.org/10.1111/j.1365-201X.2004.01331.x.
Crowley SD, Tharaux P-L, Audoly LP, Coffman TM. Exploring type I angiotensin (AT1) receptor functions through gene targeting. Acta Physiol Scand. 2004 Aug;181(4):561–70.
Crowley, S. D., et al. “Exploring type I angiotensin (AT1) receptor functions through gene targeting.” Acta Physiol Scand, vol. 181, no. 4, Aug. 2004, pp. 561–70. Pubmed, doi:10.1111/j.1365-201X.2004.01331.x.
Crowley SD, Tharaux P-L, Audoly LP, Coffman TM. Exploring type I angiotensin (AT1) receptor functions through gene targeting. Acta Physiol Scand. 2004 Aug;181(4):561–570.
Published In
Acta Physiol Scand
DOI
ISSN
0001-6772
Publication Date
August 2004
Volume
181
Issue
4
Start / End Page
561 / 570
Location
England
Related Subject Headings
- Renin-Angiotensin System
- Receptor, Angiotensin, Type 1
- Physiology
- Mice, Transgenic
- Mice
- Kidney
- Hypertension
- Humans
- Gene Targeting
- Disease Models, Animal