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In hypertension, the kidney rules.

Publication ,  Journal Article
Crowley, SD; Coffman, TM
Published in: Curr Hypertens Rep
April 2007

The renin-angiotensin system (RAS) is a critical regulator of blood pressure and fluid homeostasis. Components of the RAS, including renin, angiotensin-converting enzyme (ACE), and angiotensin type 1 (AT1) receptors, are expressed throughout the body in tissues that may impact blood pressure control. Blocking actions of individual components of the RAS lowers blood pressure. Although it has been suggested that control of sodium excretion by the kidney is the dominant mechanism for blood pressure regulation by the RAS, pharmacologic antagonists or conventional gene targeting experiments globally interrupt the RAS and cannot discriminate its actions in the kidney from other tissue compartments. Recent experiments using kidney cross-transplantation and genetically engineered mice have confirmed a major role for angiotensin II acting via AT1 receptors in the kidney in hypertension. These actions of renal AT1 receptors are required for the development of angiotensin II-dependent hypertension and cardiac hypertrophy. These findings, with previous experiments, clearly establish the critical role of the kidney in the pathogenesis of hypertension and its cardiovascular complications.

Duke Scholars

Published In

Curr Hypertens Rep

DOI

ISSN

1522-6417

Publication Date

April 2007

Volume

9

Issue

2

Start / End Page

148 / 153

Location

United States

Related Subject Headings

  • Vascular Resistance
  • Renin-Angiotensin System
  • Receptor, Angiotensin, Type 1
  • Kidney
  • Hypertrophy, Left Ventricular
  • Hypertension
  • Humans
  • Homeostasis
  • Blood Pressure
  • Animals
 

Citation

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Crowley, S. D., & Coffman, T. M. (2007). In hypertension, the kidney rules. Curr Hypertens Rep, 9(2), 148–153. https://doi.org/10.1007/s11906-007-0026-2
Crowley, Steven D., and Thomas M. Coffman. “In hypertension, the kidney rules.Curr Hypertens Rep 9, no. 2 (April 2007): 148–53. https://doi.org/10.1007/s11906-007-0026-2.
Crowley SD, Coffman TM. In hypertension, the kidney rules. Curr Hypertens Rep. 2007 Apr;9(2):148–53.
Crowley, Steven D., and Thomas M. Coffman. “In hypertension, the kidney rules.Curr Hypertens Rep, vol. 9, no. 2, Apr. 2007, pp. 148–53. Pubmed, doi:10.1007/s11906-007-0026-2.
Crowley SD, Coffman TM. In hypertension, the kidney rules. Curr Hypertens Rep. 2007 Apr;9(2):148–153.
Journal cover image

Published In

Curr Hypertens Rep

DOI

ISSN

1522-6417

Publication Date

April 2007

Volume

9

Issue

2

Start / End Page

148 / 153

Location

United States

Related Subject Headings

  • Vascular Resistance
  • Renin-Angiotensin System
  • Receptor, Angiotensin, Type 1
  • Kidney
  • Hypertrophy, Left Ventricular
  • Hypertension
  • Humans
  • Homeostasis
  • Blood Pressure
  • Animals