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Treatment of intracerebral neoplasia and neoplastic meningitis with regional delivery of oncolytic recombinant poliovirus.

Publication ,  Journal Article
Ochiai, H; Moore, SA; Archer, GE; Okamura, T; Chewning, TA; Marks, JR; Sampson, JH; Gromeier, M
Published in: Clin Cancer Res
July 15, 2004

PURPOSE: Spread to the central nervous system (CNS) and the leptomeninges is a frequent complication of systemic cancers that is associated with serious morbidity and high mortality. We have evaluated a novel therapeutic approach against CNS complications of breast cancer based on the human neuropathogen poliovirus (PV). EXPERIMENTAL DESIGN: Susceptibility to PV infection and ensuing rapid cell lysis is mediated by the cellular receptor of PV, CD155. We evaluated CD155 expression in several human breast tumor tissue specimens and cultured breast cancer cell lines. In addition, we tested an oncolytic PV recombinant for efficacy in xenotransplantation models of neoplastic meningitis and cerebral metastasis secondary to breast cancer. RESULTS: We observed that breast cancer tissues and cell lines derived thereof express CD155 at levels mediating exquisite sensitivity toward PV-induced oncolysis in the latter. An association with the immunoglobulin superfamily molecule CD155 renders breast cancer a likely target for oncolytic PV recombinants. This assumption was confirmed in xenotransplantation models for neoplastic meningitis or solitary cerebral metastasis, where local virus treatment dramatically improved survival. CONCLUSIONS: Our findings suggest oncolytic PV recombinants as a viable treatment option for CNS complications of breast cancer.

Duke Scholars

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Published In

Clin Cancer Res

DOI

ISSN

1078-0432

Publication Date

July 15, 2004

Volume

10

Issue

14

Start / End Page

4831 / 4838

Location

United States

Related Subject Headings

  • Xenograft Model Antitumor Assays
  • Survival Analysis
  • Receptors, Virus
  • Rats, Nude
  • Rats
  • Poliovirus
  • Oncology & Carcinogenesis
  • Meningeal Neoplasms
  • Membrane Proteins
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ochiai, H., Moore, S. A., Archer, G. E., Okamura, T., Chewning, T. A., Marks, J. R., … Gromeier, M. (2004). Treatment of intracerebral neoplasia and neoplastic meningitis with regional delivery of oncolytic recombinant poliovirus. Clin Cancer Res, 10(14), 4831–4838. https://doi.org/10.1158/1078-0432.CCR-03-0694
Ochiai, Hidenobu, Stephanie A. Moore, Gary E. Archer, Tatsunori Okamura, Tracy A. Chewning, Jeffrey R. Marks, John H. Sampson, and Matthias Gromeier. “Treatment of intracerebral neoplasia and neoplastic meningitis with regional delivery of oncolytic recombinant poliovirus.Clin Cancer Res 10, no. 14 (July 15, 2004): 4831–38. https://doi.org/10.1158/1078-0432.CCR-03-0694.
Ochiai H, Moore SA, Archer GE, Okamura T, Chewning TA, Marks JR, et al. Treatment of intracerebral neoplasia and neoplastic meningitis with regional delivery of oncolytic recombinant poliovirus. Clin Cancer Res. 2004 Jul 15;10(14):4831–8.
Ochiai, Hidenobu, et al. “Treatment of intracerebral neoplasia and neoplastic meningitis with regional delivery of oncolytic recombinant poliovirus.Clin Cancer Res, vol. 10, no. 14, July 2004, pp. 4831–38. Pubmed, doi:10.1158/1078-0432.CCR-03-0694.
Ochiai H, Moore SA, Archer GE, Okamura T, Chewning TA, Marks JR, Sampson JH, Gromeier M. Treatment of intracerebral neoplasia and neoplastic meningitis with regional delivery of oncolytic recombinant poliovirus. Clin Cancer Res. 2004 Jul 15;10(14):4831–4838.

Published In

Clin Cancer Res

DOI

ISSN

1078-0432

Publication Date

July 15, 2004

Volume

10

Issue

14

Start / End Page

4831 / 4838

Location

United States

Related Subject Headings

  • Xenograft Model Antitumor Assays
  • Survival Analysis
  • Receptors, Virus
  • Rats, Nude
  • Rats
  • Poliovirus
  • Oncology & Carcinogenesis
  • Meningeal Neoplasms
  • Membrane Proteins
  • Humans