beta(2)-Adrenergic receptor and adenylate cyclase gene polymorphisms affect sickle red cell adhesion.
Publication
, Journal Article
Eyler, CE; Jackson, T; Elliott, LE; De Castro, LM; Jonassaint, J; Ashley-Koch, A; Telen, MJ
Published in: Br J Haematol
April 2008
Sickle red cell (SS RBC) adhesion is thought to contribute to sickle cell disease (SCD) pathophysiology. SS RBC adhesion to laminin increases in response to adrenaline stimulation of beta(2)-adrenergic receptors (beta(2)ARs) and adenylate cyclase (ADCY6), and previous evidence suggests such activation occurs in vivo. We explored whether polymorphisms of the beta(2)AR and ADCY6 genes (ADRB2 and ADCY6, respectively) affect RBC adhesion to laminin. We found that the beta(2)AR arg(16)-->gly substitution and two non-coding ADCY6 polymorphisms were associated with elevated adhesion. We postulate that ADRB2 and ADCY6 polymorphisms may influence SCD severity through the mechanism of RBC adhesion.
Duke Scholars
Published In
Br J Haematol
DOI
EISSN
1365-2141
Publication Date
April 2008
Volume
141
Issue
1
Start / End Page
105 / 108
Location
England
Related Subject Headings
- Receptors, Adrenergic, beta-2
- Polymorphism, Single Nucleotide
- Laminin
- Immunology
- Humans
- Genotype
- Erythrocytes
- Cell Adhesion
- Anemia, Sickle Cell
- Adenylyl Cyclases
Citation
APA
Chicago
ICMJE
MLA
NLM
Eyler, C. E., Jackson, T., Elliott, L. E., De Castro, L. M., Jonassaint, J., Ashley-Koch, A., & Telen, M. J. (2008). beta(2)-Adrenergic receptor and adenylate cyclase gene polymorphisms affect sickle red cell adhesion. Br J Haematol, 141(1), 105–108. https://doi.org/10.1111/j.1365-2141.2008.07008.x
Eyler, Christine E., Terry Jackson, Laine E. Elliott, Laura M. De Castro, Jude Jonassaint, Allison Ashley-Koch, and Marilyn J. Telen. “beta(2)-Adrenergic receptor and adenylate cyclase gene polymorphisms affect sickle red cell adhesion.” Br J Haematol 141, no. 1 (April 2008): 105–8. https://doi.org/10.1111/j.1365-2141.2008.07008.x.
Eyler CE, Jackson T, Elliott LE, De Castro LM, Jonassaint J, Ashley-Koch A, et al. beta(2)-Adrenergic receptor and adenylate cyclase gene polymorphisms affect sickle red cell adhesion. Br J Haematol. 2008 Apr;141(1):105–8.
Eyler, Christine E., et al. “beta(2)-Adrenergic receptor and adenylate cyclase gene polymorphisms affect sickle red cell adhesion.” Br J Haematol, vol. 141, no. 1, Apr. 2008, pp. 105–08. Pubmed, doi:10.1111/j.1365-2141.2008.07008.x.
Eyler CE, Jackson T, Elliott LE, De Castro LM, Jonassaint J, Ashley-Koch A, Telen MJ. beta(2)-Adrenergic receptor and adenylate cyclase gene polymorphisms affect sickle red cell adhesion. Br J Haematol. 2008 Apr;141(1):105–108.
Published In
Br J Haematol
DOI
EISSN
1365-2141
Publication Date
April 2008
Volume
141
Issue
1
Start / End Page
105 / 108
Location
England
Related Subject Headings
- Receptors, Adrenergic, beta-2
- Polymorphism, Single Nucleotide
- Laminin
- Immunology
- Humans
- Genotype
- Erythrocytes
- Cell Adhesion
- Anemia, Sickle Cell
- Adenylyl Cyclases