Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides.
Publication
, Journal Article
Laskowitz, DT; Thekdi, AD; Thekdi, SD; Han, SK; Myers, JK; Pizzo, SV; Bennett, ER
Published in: Exp Neurol
January 2001
Apolipoprotein E plays an important role in recovery from acute brain injury and risk of developing Alzheimer's disease. We demonstrate that biologically relevant concentrations of apoE suppress microglial activation and release of TNFalpha and NO in a dose-dependent fashion. Peptides derived from the apoE receptor-binding region mimic the effects of the intact protein, whereas deletion of apoE residues 146-149 abolishes peptide bioactivity. These results are consistent with the hypothesis that apoE modulates microglial function by binding specific cell surface receptors and that the immunomodulatory effects of apoE in the central nervous system may account for its role in acute and chronic neurological disease.
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Published In
Exp Neurol
DOI
ISSN
0014-4886
Publication Date
January 2001
Volume
167
Issue
1
Start / End Page
74 / 85
Location
United States
Related Subject Headings
- Tumor Necrosis Factor-alpha
- Substrate Specificity
- Structure-Activity Relationship
- Sequence Deletion
- Recombinant Proteins
- Receptors, Immunologic
- Protein Structure, Secondary
- Protein Isoforms
- Peptide Fragments
- Nitric Oxide
Citation
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Laskowitz, D. T., Thekdi, A. D., Thekdi, S. D., Han, S. K., Myers, J. K., Pizzo, S. V., & Bennett, E. R. (2001). Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides. Exp Neurol, 167(1), 74–85. https://doi.org/10.1006/exnr.2001.7541
Laskowitz, D. T., A. D. Thekdi, S. D. Thekdi, S. K. Han, J. K. Myers, S. V. Pizzo, and E. R. Bennett. “Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides.” Exp Neurol 167, no. 1 (January 2001): 74–85. https://doi.org/10.1006/exnr.2001.7541.
Laskowitz DT, Thekdi AD, Thekdi SD, Han SK, Myers JK, Pizzo SV, et al. Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides. Exp Neurol. 2001 Jan;167(1):74–85.
Laskowitz, D. T., et al. “Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides.” Exp Neurol, vol. 167, no. 1, Jan. 2001, pp. 74–85. Pubmed, doi:10.1006/exnr.2001.7541.
Laskowitz DT, Thekdi AD, Thekdi SD, Han SK, Myers JK, Pizzo SV, Bennett ER. Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides. Exp Neurol. 2001 Jan;167(1):74–85.
Published In
Exp Neurol
DOI
ISSN
0014-4886
Publication Date
January 2001
Volume
167
Issue
1
Start / End Page
74 / 85
Location
United States
Related Subject Headings
- Tumor Necrosis Factor-alpha
- Substrate Specificity
- Structure-Activity Relationship
- Sequence Deletion
- Recombinant Proteins
- Receptors, Immunologic
- Protein Structure, Secondary
- Protein Isoforms
- Peptide Fragments
- Nitric Oxide