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Effects of ocular carteolol and timolol on plasma high-density lipoprotein cholesterol level.

Publication ,  Journal Article
Freedman, SF; Freedman, NJ; Shields, MB; Lobaugh, B; Samsa, GP; Keates, EU; Ollie, A
Published in: Am J Ophthalmol
November 15, 1993

Fifty-eight healthy, normolipidemic adult men participated in a prospective, masked, randomized crossover study designed to compare the effects of two topical nonselective beta-adrenergic antagonists, carteolol and timolol, on plasma high-density lipoprotein cholesterol levels. Two eight-week treatment periods were separated by an eight-week drug-free period. Carteolol 1.0% or timolol 0.5% was used, one drop twice daily, in both eyes without nasolacrimal occlusion. Fresh plasma was assayed for levels of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, and apolipoproteins A-I and B-100. With indistinguishable effects on intraocular pressure, carteolol and timolol induced different (P = .013) decrements in high-density lipoprotein cholesterol levels. Carteolol treatment decreased high-density lipoprotein cholesterol levels by 3.3% (-0.04 mmol/l) and raised the ratio of total to high-density lipoprotein cholesterol levels by 4.0% (0.15 unit); timolol treatment decreased high-density lipoprotein cholesterol levels by 8.0% (-0.10 mmol/l) and raised the ratio of total to high-density lipoprotein cholesterol levels by 10.0% (0.37 unit). There was no differential drug effect on the other lipid variables measured. Ocular nonselective beta-adrenergic antagonist therapy can produce clinically relevant decrements in high-density lipoprotein cholesterol levels in healthy men.

Duke Scholars

Published In

Am J Ophthalmol

DOI

ISSN

0002-9394

Publication Date

November 15, 1993

Volume

116

Issue

5

Start / End Page

600 / 611

Location

United States

Related Subject Headings

  • Timolol
  • Prospective Studies
  • Ophthalmology & Optometry
  • Ophthalmic Solutions
  • Middle Aged
  • Male
  • Lipids
  • Intraocular Pressure
  • Humans
  • Eye
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Freedman, S. F., Freedman, N. J., Shields, M. B., Lobaugh, B., Samsa, G. P., Keates, E. U., & Ollie, A. (1993). Effects of ocular carteolol and timolol on plasma high-density lipoprotein cholesterol level. Am J Ophthalmol, 116(5), 600–611. https://doi.org/10.1016/s0002-9394(14)73203-9
Freedman, S. F., N. J. Freedman, M. B. Shields, B. Lobaugh, G. P. Samsa, E. U. Keates, and A. Ollie. “Effects of ocular carteolol and timolol on plasma high-density lipoprotein cholesterol level.Am J Ophthalmol 116, no. 5 (November 15, 1993): 600–611. https://doi.org/10.1016/s0002-9394(14)73203-9.
Freedman SF, Freedman NJ, Shields MB, Lobaugh B, Samsa GP, Keates EU, et al. Effects of ocular carteolol and timolol on plasma high-density lipoprotein cholesterol level. Am J Ophthalmol. 1993 Nov 15;116(5):600–11.
Freedman, S. F., et al. “Effects of ocular carteolol and timolol on plasma high-density lipoprotein cholesterol level.Am J Ophthalmol, vol. 116, no. 5, Nov. 1993, pp. 600–11. Pubmed, doi:10.1016/s0002-9394(14)73203-9.
Freedman SF, Freedman NJ, Shields MB, Lobaugh B, Samsa GP, Keates EU, Ollie A. Effects of ocular carteolol and timolol on plasma high-density lipoprotein cholesterol level. Am J Ophthalmol. 1993 Nov 15;116(5):600–611.
Journal cover image

Published In

Am J Ophthalmol

DOI

ISSN

0002-9394

Publication Date

November 15, 1993

Volume

116

Issue

5

Start / End Page

600 / 611

Location

United States

Related Subject Headings

  • Timolol
  • Prospective Studies
  • Ophthalmology & Optometry
  • Ophthalmic Solutions
  • Middle Aged
  • Male
  • Lipids
  • Intraocular Pressure
  • Humans
  • Eye