Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation.
Publication
, Journal Article
Yang, W; Sheng, H; Warner, DS; Paschen, W
Published in: J Cereb Blood Flow Metab
May 2008
This study was designed to investigate whether small ubiquitin-like modifier (SUMO) conjugation is activated after focal cerebral ischemia. Transient ischemia induced a dramatic increase in SUMO2/3 protein conjugates. The most pronounced changes were found in the parietal cortex. SUMO2/3 conjugation was particularly high in neurons located at the border of the middle cerebral artery territory where sumoylated proteins translocated to the nucleus. Considering the marked effect of SUMO conjugation on the function of target proteins, it is very likely that the postischemic activation of sumoylation has a significant effect on the fate of neurons exposed to transient ischemia.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
J Cereb Blood Flow Metab
DOI
ISSN
0271-678X
Publication Date
May 2008
Volume
28
Issue
5
Start / End Page
892 / 896
Location
United States
Related Subject Headings
- Small Ubiquitin-Related Modifier Proteins
- SUMO-1 Protein
- Rats, Wistar
- Rats
- Parietal Lobe
- Neurology & Neurosurgery
- Male
- Ischemic Attack, Transient
- Infarction, Middle Cerebral Artery
- Immunohistochemistry
Citation
APA
Chicago
ICMJE
MLA
NLM
Yang, W., Sheng, H., Warner, D. S., & Paschen, W. (2008). Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation. J Cereb Blood Flow Metab, 28(5), 892–896. https://doi.org/10.1038/sj.jcbfm.9600601
Yang, Wei, Huaxin Sheng, David S. Warner, and Wulf Paschen. “Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation.” J Cereb Blood Flow Metab 28, no. 5 (May 2008): 892–96. https://doi.org/10.1038/sj.jcbfm.9600601.
Yang W, Sheng H, Warner DS, Paschen W. Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation. J Cereb Blood Flow Metab. 2008 May;28(5):892–6.
Yang, Wei, et al. “Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation.” J Cereb Blood Flow Metab, vol. 28, no. 5, May 2008, pp. 892–96. Pubmed, doi:10.1038/sj.jcbfm.9600601.
Yang W, Sheng H, Warner DS, Paschen W. Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation. J Cereb Blood Flow Metab. 2008 May;28(5):892–896.
Published In
J Cereb Blood Flow Metab
DOI
ISSN
0271-678X
Publication Date
May 2008
Volume
28
Issue
5
Start / End Page
892 / 896
Location
United States
Related Subject Headings
- Small Ubiquitin-Related Modifier Proteins
- SUMO-1 Protein
- Rats, Wistar
- Rats
- Parietal Lobe
- Neurology & Neurosurgery
- Male
- Ischemic Attack, Transient
- Infarction, Middle Cerebral Artery
- Immunohistochemistry