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Nonalcoholic steatohepatitis and nonalcoholic Fatty liver disease in young women with polycystic ovary syndrome.

Publication ,  Journal Article
Setji, TL; Holland, ND; Sanders, LL; Pereira, KC; Diehl, AM; Brown, AJ
Published in: J Clin Endocrinol Metab
May 2006

CONTEXT: Nonalcoholic fatty liver disease and polycystic ovary syndrome (PCOS) are both associated with insulin resistance. Thus, women with PCOS may have an increased prevalence of nonalcoholic fatty liver disease, including nonalcoholic steatohepatitis (NASH). OBJECTIVE: The objective of the study was to determine the prevalence and characteristics of NASH and abnormal aminotransferase activity in women with PCOS. DESIGN: The study is a retrospective chart review. SETTING: The setting is an academic endocrinology clinic. PATIENTS: Patients were 200 women with PCOS, defined as irregular menses and hyperandrogenism. MAIN OUTCOME MEASURES: Biopsy-documented NASH and aminotransferase levels were the main outcome measures. RESULTS: Fifteen percent (29 of 200) had aspartate aminotransferase and/or alanine aminotransferase more than 60 U/liter. Women with aminotransferase elevations had lower high-density lipoprotein (HDL) (41 vs. 50 mg/dl, P = 0.006), higher triglycerides (174 vs. 129 mg/dl, P = 0.024), and higher fasting insulin (21 vs. 12 microIU/ml, P = 0.036) compared with women with normal aminotransferases. Six women (mean age 29 yr) with persistent aminotransferase elevations underwent liver biopsy. All six had NASH with fibrosis. Compared with the 194 of 200 PCOS women who did not undergo biopsy, women with biopsy-documented NASH had lower HDL (median 34 vs. 50 mg/dl, P < 0.001), and higher triglycerides (245 vs. 132 mg/dl, P = 0.025), fasting insulin (26 vs. 13 microIU/ml, P = 0.038), aspartate aminotransferase (144 vs. 22 U/liter, P < 0.001), and alanine aminotransferase (143 vs. 28 U/liter, P < 0.001). CONCLUSION: Abnormal aminotransferase activity is common in women with PCOS. Low HDL, high triglycerides, and high fasting insulin were associated with abnormal aminotransferase activity. Some women already had evidence of NASH with fibrosis. Further studies are needed to evaluate whether to screen PCOS women for liver disease at an earlier age than is currently recommended for the general population.

Duke Scholars

Published In

J Clin Endocrinol Metab

DOI

ISSN

0021-972X

Publication Date

May 2006

Volume

91

Issue

5

Start / End Page

1741 / 1747

Location

United States

Related Subject Headings

  • Polycystic Ovary Syndrome
  • Middle Aged
  • Metabolic Syndrome
  • Liver Function Tests
  • Lipids
  • Insulin
  • Humans
  • Hepatitis
  • Female
  • Fatty Liver
 

Citation

APA
Chicago
ICMJE
MLA
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Setji, T. L., Holland, N. D., Sanders, L. L., Pereira, K. C., Diehl, A. M., & Brown, A. J. (2006). Nonalcoholic steatohepatitis and nonalcoholic Fatty liver disease in young women with polycystic ovary syndrome. J Clin Endocrinol Metab, 91(5), 1741–1747. https://doi.org/10.1210/jc.2005-2774
Setji, Tracy L., Nicole D. Holland, Linda L. Sanders, Kathy C. Pereira, Anna Mae Diehl, and Ann J. Brown. “Nonalcoholic steatohepatitis and nonalcoholic Fatty liver disease in young women with polycystic ovary syndrome.J Clin Endocrinol Metab 91, no. 5 (May 2006): 1741–47. https://doi.org/10.1210/jc.2005-2774.
Setji TL, Holland ND, Sanders LL, Pereira KC, Diehl AM, Brown AJ. Nonalcoholic steatohepatitis and nonalcoholic Fatty liver disease in young women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2006 May;91(5):1741–7.
Setji, Tracy L., et al. “Nonalcoholic steatohepatitis and nonalcoholic Fatty liver disease in young women with polycystic ovary syndrome.J Clin Endocrinol Metab, vol. 91, no. 5, May 2006, pp. 1741–47. Pubmed, doi:10.1210/jc.2005-2774.
Setji TL, Holland ND, Sanders LL, Pereira KC, Diehl AM, Brown AJ. Nonalcoholic steatohepatitis and nonalcoholic Fatty liver disease in young women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2006 May;91(5):1741–1747.
Journal cover image

Published In

J Clin Endocrinol Metab

DOI

ISSN

0021-972X

Publication Date

May 2006

Volume

91

Issue

5

Start / End Page

1741 / 1747

Location

United States

Related Subject Headings

  • Polycystic Ovary Syndrome
  • Middle Aged
  • Metabolic Syndrome
  • Liver Function Tests
  • Lipids
  • Insulin
  • Humans
  • Hepatitis
  • Female
  • Fatty Liver