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Concurrent chemoradiotherapy in resected extrahepatic cholangiocarcinoma.

Publication ,  Journal Article
Nelson, JW; Ghafoori, AP; Willett, CG; Tyler, DS; Pappas, TN; Clary, BM; Hurwitz, HI; Bendell, JC; Morse, MA; Clough, RW; Czito, BG
Published in: Int J Radiat Oncol Biol Phys
January 1, 2009
Published version (DOI) Link to item

PURPOSE: Extrahepatic cholangiocarcinoma is a rare malignancy. Despite radical resection, survival remains poor, with high rates of local and distant failure. To clarify the role of radiotherapy with chemotherapy, we performed a retrospective analysis of resected patients who had undergone chemoradiotherapy. METHODS AND MATERIALS: A total of 45 patients (13 with proximal and 32 with distal disease) underwent resection plus radiotherapy (median dose, 50.4 Gy). All but 1 patient received concurrent fluoropyrimidine-based chemotherapy. The median follow-up was 30 months for all patients and 40 months for survivors. RESULTS: Of the 45 patients, 33 underwent adjuvant radiotherapy, and 12 were treated neoadjuvantly. The 5-year actuarial overall survival, disease-free survival, metastasis-free survival, and locoregional control rates were 33%, 37%, 42%, and 78%, respectively. The median survival was 34 months. No patient died perioperatively. Patient age

Duke Scholars

Christopher G. Willett
Author Christopher G. Willett Radiation Oncology
Theodore N. Pappas
Author Theodore N. Pappas Surgery, Minimally Invasive Surgery
Herbert Ira Hurwitz
Author Herbert Ira Hurwitz Medicine, Medical Oncology
Michael Aaron Morse
Author Michael Aaron Morse Medicine, Medical Oncology
Brian Gary Czito
Author Brian Gary Czito Radiation Oncology

Published In

Int J Radiat Oncol Biol Phys

DOI

10.1016/j.ijrobp.2008.07.008

EISSN

1879-355X

Publication Date

January 1, 2009

Volume

73

Issue

1

Start / End Page

148 / 153

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Survival Rate
  • Survival Analysis
  • Retrospective Studies
  • Radiotherapy, Conformal
  • Prevalence
  • Oncology & Carcinogenesis
  • North Carolina
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Nelson, J. W., Ghafoori, A. P., Willett, C. G., Tyler, D. S., Pappas, T. N., Clary, B. M., … Czito, B. G. (2009). Concurrent chemoradiotherapy in resected extrahepatic cholangiocarcinoma. Int J Radiat Oncol Biol Phys, 73(1), 148–153. https://doi.org/10.1016/j.ijrobp.2008.07.008
Nelson, John W., A Paiman Ghafoori, Christopher G. Willett, Douglas S. Tyler, Theodore N. Pappas, Bryan M. Clary, Herbert I. Hurwitz, et al. “Concurrent chemoradiotherapy in resected extrahepatic cholangiocarcinoma.” Int J Radiat Oncol Biol Phys 73, no. 1 (January 1, 2009): 148–53. https://doi.org/10.1016/j.ijrobp.2008.07.008.
Nelson JW, Ghafoori AP, Willett CG, Tyler DS, Pappas TN, Clary BM, et al. Concurrent chemoradiotherapy in resected extrahepatic cholangiocarcinoma. Int J Radiat Oncol Biol Phys. 2009 Jan 1;73(1):148–53.
Nelson, John W., et al. “Concurrent chemoradiotherapy in resected extrahepatic cholangiocarcinoma.” Int J Radiat Oncol Biol Phys, vol. 73, no. 1, Jan. 2009, pp. 148–53. Pubmed, doi:10.1016/j.ijrobp.2008.07.008.
Nelson JW, Ghafoori AP, Willett CG, Tyler DS, Pappas TN, Clary BM, Hurwitz HI, Bendell JC, Morse MA, Clough RW, Czito BG. Concurrent chemoradiotherapy in resected extrahepatic cholangiocarcinoma. Int J Radiat Oncol Biol Phys. 2009 Jan 1;73(1):148–153.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

10.1016/j.ijrobp.2008.07.008

EISSN

1879-355X

Publication Date

January 1, 2009

Volume

73

Issue

1

Start / End Page

148 / 153

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Survival Rate
  • Survival Analysis
  • Retrospective Studies
  • Radiotherapy, Conformal
  • Prevalence
  • Oncology & Carcinogenesis
  • North Carolina
  • Middle Aged
  • Male