Scholars@Duke publication: Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.

Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.

Publication , Journal Article

Haynes, BF; Fleming, J; St Clair, EW; Katinger, H; Stiegler, G; Kunert, R; Robinson, J; Scearce, RM; Plonk, K; Staats, HF; Ortel, TL; Alam, SM ...

Published in: Science

June 24, 2005

Published version (DOI) Link to item

The design of a human immunodeficiency virus-1 (HIV-1) immunogen that can induce broadly reactive neutralizing antibodies is a major goal of HIV-1 vaccine development. Although rare human monoclonal antibodies (mAbs) exist that broadly neutralize HIV-1, HIV-1 envelope immunogens do not induce these antibody specificities. Here we demonstrate that the two most broadly reactive HIV-1 envelope gp41 human mAbs, 2F5 and 4E10, are polyspecific autoantibodies reactive with the phospholipid cardiolipin. Thus, current HIV-1 vaccines may not induce these types of antibodies because of autoantigen mimicry of the conserved membrane-proximal epitopes of the virus. These results may have important implications for generating effective neutralizing antibody responses by using HIV-1 vaccines.

Duke Scholars

Author Barton Ford Haynes Medicine, Duke Human Vaccine Institute

Author Eugene William St. Clair Medicine, Rheumatology and Immunology

Author Herman Ford Staats Pathology

Author Thomas Lee Ortel Medicine, Hematology

Author S. Munir Alam Medicine, Duke Human Vaccine Institute

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Published In

Science

DOI

10.1126/science.1111781

EISSN

1095-9203

Publication Date

June 24, 2005

Volume

308

Issue

5730

Start / End Page

1906 / 1908

Location

United States

Related Subject Headings

Neutralization Tests
Molecular Mimicry
Mice
Humans
HIV-1
HIV Infections
HIV Envelope Protein gp41
HIV Antibodies
General Science & Technology
Epitopes

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Chicago

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Haynes, B. F., Fleming, J., St Clair, E. W., Katinger, H., Stiegler, G., Kunert, R., … Alam, S. M. (2005). Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies. Science, 308(5730), 1906–1908. https://doi.org/10.1126/science.1111781

Haynes, Barton F., Judith Fleming, E William St Clair, Herman Katinger, Gabriela Stiegler, Renate Kunert, James Robinson, et al. “Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.” Science 308, no. 5730 (June 24, 2005): 1906–8. https://doi.org/10.1126/science.1111781.

Haynes BF, Fleming J, St Clair EW, Katinger H, Stiegler G, Kunert R, et al. Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies. Science. 2005 Jun 24;308(5730):1906–8.

Haynes, Barton F., et al. “Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.” Science, vol. 308, no. 5730, June 2005, pp. 1906–08. Pubmed, doi:10.1126/science.1111781.

Haynes BF, Fleming J, St Clair EW, Katinger H, Stiegler G, Kunert R, Robinson J, Scearce RM, Plonk K, Staats HF, Ortel TL, Liao H-X, Alam SM. Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies. Science. 2005 Jun 24;308(5730):1906–1908.

Published In

Science

DOI

10.1126/science.1111781

EISSN

1095-9203

Publication Date

June 24, 2005

Volume

308

Issue

5730

Start / End Page

1906 / 1908

Location

United States

Related Subject Headings

Neutralization Tests
Molecular Mimicry
Mice
Humans
HIV-1
HIV Infections
HIV Envelope Protein gp41
HIV Antibodies
General Science & Technology
Epitopes