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Genes implicated in serotonergic and dopaminergic functioning predict BMI categories.

Publication ,  Journal Article
Fuemmeler, BF; Agurs-Collins, TD; McClernon, FJ; Kollins, SH; Kail, ME; Bergen, AW; Ashley-Koch, AE
Published in: Obesity (Silver Spring)
February 2008

OBJECTIVE: This study addressed the hypothesis that variation in genes associated with dopamine function (SLC6A3, DRD2, DRD4), serotonin function (SLC6A4, and regulation of monoamine levels (MAOA) may be predictive of BMI categories (obese and overweight + obese) in young adulthood and of changes in BMI as adolescents transition into young adulthood. Interactions with gender and race/ethnicity were also examined. METHODS AND PROCEDURES: Participants were a subsample of individuals from the National Longitudinal Study of Adolescent Health (Add Health), a nationally representative sample of adolescents followed from 1995 to 2002. The sample analyzed included a subset of 1,584 unrelated individuals with genotype data. Multiple logistic regressions were conducted to evaluate the associations between genotypes and obesity (BMI > 29.9) or overweight + obese combined (BMI > or = 25) with normal weight (BMI = 18.5-24.9) as a referent. Linear regression models were used to examine change in BMI from adolescence to young adulthood. RESULTS: Significant associations were found between SLC6A4 5HTTLPR and categories of BMI, and between MAOA promoter variable number tandem repeat (VNTR) among men and categories of BMI. Stratified analyses revealed that the association between these two genes and excess BMI was significant for men overall and for white and Hispanic men specifically. Linear regression models indicated a significant effect of SLC6A4 5HTTLPR on change in BMI from adolescence to young adulthood. DISCUSSION: Our findings lend further support to the involvement of genes implicated in dopamine and serotonin regulation on energy balance.

Duke Scholars

Published In

Obesity (Silver Spring)

DOI

ISSN

1930-7381

Publication Date

February 2008

Volume

16

Issue

2

Start / End Page

348 / 355

Location

United States

Related Subject Headings

  • White People
  • Sex Characteristics
  • Serotonin Plasma Membrane Transport Proteins
  • Serotonin
  • Receptors, Dopamine D4
  • Predictive Value of Tests
  • Obesity
  • Monoamine Oxidase
  • Male
  • Longitudinal Studies
 

Citation

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MLA
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Fuemmeler, B. F., Agurs-Collins, T. D., McClernon, F. J., Kollins, S. H., Kail, M. E., Bergen, A. W., & Ashley-Koch, A. E. (2008). Genes implicated in serotonergic and dopaminergic functioning predict BMI categories. Obesity (Silver Spring), 16(2), 348–355. https://doi.org/10.1038/oby.2007.65
Fuemmeler, Bernard F., Tanya D. Agurs-Collins, F Joseph McClernon, Scott H. Kollins, Melanie E. Kail, Andrew W. Bergen, and Allison E. Ashley-Koch. “Genes implicated in serotonergic and dopaminergic functioning predict BMI categories.Obesity (Silver Spring) 16, no. 2 (February 2008): 348–55. https://doi.org/10.1038/oby.2007.65.
Fuemmeler BF, Agurs-Collins TD, McClernon FJ, Kollins SH, Kail ME, Bergen AW, et al. Genes implicated in serotonergic and dopaminergic functioning predict BMI categories. Obesity (Silver Spring). 2008 Feb;16(2):348–55.
Fuemmeler, Bernard F., et al. “Genes implicated in serotonergic and dopaminergic functioning predict BMI categories.Obesity (Silver Spring), vol. 16, no. 2, Feb. 2008, pp. 348–55. Pubmed, doi:10.1038/oby.2007.65.
Fuemmeler BF, Agurs-Collins TD, McClernon FJ, Kollins SH, Kail ME, Bergen AW, Ashley-Koch AE. Genes implicated in serotonergic and dopaminergic functioning predict BMI categories. Obesity (Silver Spring). 2008 Feb;16(2):348–355.
Journal cover image

Published In

Obesity (Silver Spring)

DOI

ISSN

1930-7381

Publication Date

February 2008

Volume

16

Issue

2

Start / End Page

348 / 355

Location

United States

Related Subject Headings

  • White People
  • Sex Characteristics
  • Serotonin Plasma Membrane Transport Proteins
  • Serotonin
  • Receptors, Dopamine D4
  • Predictive Value of Tests
  • Obesity
  • Monoamine Oxidase
  • Male
  • Longitudinal Studies