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Beta-arrestins and cell signaling.

Publication ,  Journal Article
DeWire, SM; Ahn, S; Lefkowitz, RJ; Shenoy, SK
Published in: Annu Rev Physiol
2007

Upon their discovery, beta-arrestins 1 and 2 were named for their capacity to sterically hinder the G protein coupling of agonist-activated seven-transmembrane receptors, ultimately resulting in receptor desensitization. Surprisingly, recent evidence shows that beta-arrestins can also function to activate signaling cascades independently of G protein activation. By serving as multiprotein scaffolds, the beta-arrestins bring elements of specific signaling pathways into close proximity. beta-Arrestin regulation has been demonstrated for an ever-increasing number of signaling molecules, including the mitogen-activated protein kinases ERK, JNK, and p38 as well as Akt, PI3 kinase, and RhoA. In addition, investigators are discovering new roles for beta-arrestins in nuclear functions. Here, we review the signaling capacities of these versatile adapter molecules and discuss the possible implications for cellular processes such as chemotaxis and apoptosis.

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Published In

Annu Rev Physiol

DOI

ISSN

0066-4278

Publication Date

2007

Volume

69

Start / End Page

483 / 510

Location

United States

Related Subject Headings

  • p38 Mitogen-Activated Protein Kinases
  • beta-Arrestins
  • Signal Transduction
  • Protein Conformation
  • Physiology
  • Phosphorylation
  • Mitogen-Activated Protein Kinases
  • Janus Kinases
  • Humans
  • Extracellular Signal-Regulated MAP Kinases
 

Citation

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DeWire, S. M., Ahn, S., Lefkowitz, R. J., & Shenoy, S. K. (2007). Beta-arrestins and cell signaling. Annu Rev Physiol, 69, 483–510. https://doi.org/10.1146/annurev.physiol.69.022405.154749
DeWire, Scott M., Seungkirl Ahn, Robert J. Lefkowitz, and Sudha K. Shenoy. “Beta-arrestins and cell signaling.Annu Rev Physiol 69 (2007): 483–510. https://doi.org/10.1146/annurev.physiol.69.022405.154749.
DeWire SM, Ahn S, Lefkowitz RJ, Shenoy SK. Beta-arrestins and cell signaling. Annu Rev Physiol. 2007;69:483–510.
DeWire, Scott M., et al. “Beta-arrestins and cell signaling.Annu Rev Physiol, vol. 69, 2007, pp. 483–510. Pubmed, doi:10.1146/annurev.physiol.69.022405.154749.
DeWire SM, Ahn S, Lefkowitz RJ, Shenoy SK. Beta-arrestins and cell signaling. Annu Rev Physiol. 2007;69:483–510.

Published In

Annu Rev Physiol

DOI

ISSN

0066-4278

Publication Date

2007

Volume

69

Start / End Page

483 / 510

Location

United States

Related Subject Headings

  • p38 Mitogen-Activated Protein Kinases
  • beta-Arrestins
  • Signal Transduction
  • Protein Conformation
  • Physiology
  • Phosphorylation
  • Mitogen-Activated Protein Kinases
  • Janus Kinases
  • Humans
  • Extracellular Signal-Regulated MAP Kinases