
Pharmacokinetics of antifungal agents in children.
Publication
, Journal Article
Watt, K; Benjamin, DK; Cohen-Wolkowiez, M
Published in: Early Hum Dev
March 2011
Invasive fungal infections in immunocompromised children are common and often fatal. The first antifungal agents such as amphotericin B and fluconazole offered effective treatment, but their use was often limited by toxicity and resistance. Numerous new antifungal agents have since been developed and appear to be as effective. Most dosing and safety trials have been done in adults, and extrapolation of this data to children has proven inadequate. We reviewed the literature regarding the pharmacokinetics/pharmacodynamics (PK/PD) and safety of antifungal agents with an emphasis on the newer azoles and echinocandins. From a small but growing number of PK/PD trials, better dosing guidelines have been developed.
Duke Scholars
Published In
Early Hum Dev
DOI
EISSN
1872-6232
Publication Date
March 2011
Volume
87 Suppl 1
Issue
Suppl 1
Start / End Page
S61 / S65
Location
Ireland
Related Subject Headings
- Triazoles
- Preventive Medicine
- Polyenes
- Pediatrics
- Nucleosides
- Mycoses
- Immunocompromised Host
- Humans
- Echinocandins
- Child
Citation
APA
Chicago
ICMJE
MLA
NLM
Watt, K., Benjamin, D. K., & Cohen-Wolkowiez, M. (2011). Pharmacokinetics of antifungal agents in children. Early Hum Dev, 87 Suppl 1(Suppl 1), S61–S65. https://doi.org/10.1016/j.earlhumdev.2011.01.014
Watt, Kevin, Daniel K. Benjamin, and Michael Cohen-Wolkowiez. “Pharmacokinetics of antifungal agents in children.” Early Hum Dev 87 Suppl 1, no. Suppl 1 (March 2011): S61–65. https://doi.org/10.1016/j.earlhumdev.2011.01.014.
Watt K, Benjamin DK, Cohen-Wolkowiez M. Pharmacokinetics of antifungal agents in children. Early Hum Dev. 2011 Mar;87 Suppl 1(Suppl 1):S61–5.
Watt, Kevin, et al. “Pharmacokinetics of antifungal agents in children.” Early Hum Dev, vol. 87 Suppl 1, no. Suppl 1, Mar. 2011, pp. S61–65. Pubmed, doi:10.1016/j.earlhumdev.2011.01.014.
Watt K, Benjamin DK, Cohen-Wolkowiez M. Pharmacokinetics of antifungal agents in children. Early Hum Dev. 2011 Mar;87 Suppl 1(Suppl 1):S61–S65.

Published In
Early Hum Dev
DOI
EISSN
1872-6232
Publication Date
March 2011
Volume
87 Suppl 1
Issue
Suppl 1
Start / End Page
S61 / S65
Location
Ireland
Related Subject Headings
- Triazoles
- Preventive Medicine
- Polyenes
- Pediatrics
- Nucleosides
- Mycoses
- Immunocompromised Host
- Humans
- Echinocandins
- Child