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Ontogeny of T-cell precursors: a model for the initial stages of human T-cell development.

Publication ,  Journal Article
Haynes, BF; Denning, SM; Singer, KH; Kurtzberg, J
Published in: Immunol Today
March 1989

Although most investigators agree that the CD4- CD8- CD3- thymocyte subset represents the most immature intrathymic T cell capable of repopulating the thymus in vivo, little is known of the earliest stages of human T-cell development. Using mAbs to hematopoietic and T-cell lineage molecules in quantitative immunofluorescence studies, new insight has been gained regarding the phenotype of human T-cell precursors before and after colonization of human thymic rudiment. In this article, Barton Haynes and colleagues discuss the sequential expression of CD7, CD4, CD8, CD3, CD2, CD1, CD45, TCR gamma delta and TCR alpha beta, and propose a model defining the stages of T-cell precursors during fetal ontogeny.

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Published In

Immunol Today

DOI

ISSN

0167-5699

Publication Date

March 1989

Volume

10

Issue

3

Start / End Page

87 / 91

Location

England

Related Subject Headings

  • T-Lymphocytes
  • Models, Biological
  • Immunology
  • Humans
  • Hematopoietic Stem Cells
  • Embryonic and Fetal Development
  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, CD7
  • 3204 Immunology
  • 3101 Biochemistry and cell biology
 

Citation

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Haynes, B. F., Denning, S. M., Singer, K. H., & Kurtzberg, J. (1989). Ontogeny of T-cell precursors: a model for the initial stages of human T-cell development. Immunol Today, 10(3), 87–91. https://doi.org/10.1016/0167-5699(89)90232-6
Haynes, B. F., S. M. Denning, K. H. Singer, and J. Kurtzberg. “Ontogeny of T-cell precursors: a model for the initial stages of human T-cell development.Immunol Today 10, no. 3 (March 1989): 87–91. https://doi.org/10.1016/0167-5699(89)90232-6.
Haynes BF, Denning SM, Singer KH, Kurtzberg J. Ontogeny of T-cell precursors: a model for the initial stages of human T-cell development. Immunol Today. 1989 Mar;10(3):87–91.
Haynes, B. F., et al. “Ontogeny of T-cell precursors: a model for the initial stages of human T-cell development.Immunol Today, vol. 10, no. 3, Mar. 1989, pp. 87–91. Pubmed, doi:10.1016/0167-5699(89)90232-6.
Haynes BF, Denning SM, Singer KH, Kurtzberg J. Ontogeny of T-cell precursors: a model for the initial stages of human T-cell development. Immunol Today. 1989 Mar;10(3):87–91.

Published In

Immunol Today

DOI

ISSN

0167-5699

Publication Date

March 1989

Volume

10

Issue

3

Start / End Page

87 / 91

Location

England

Related Subject Headings

  • T-Lymphocytes
  • Models, Biological
  • Immunology
  • Humans
  • Hematopoietic Stem Cells
  • Embryonic and Fetal Development
  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, CD7
  • 3204 Immunology
  • 3101 Biochemistry and cell biology