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Plexin-D1 is a novel regulator of germinal centers and humoral immune responses.

Publication ,  Journal Article
Holl, EK; O'Connor, BP; Holl, TM; Roney, KE; Zimmermann, AG; Jha, S; Kelsoe, G; Ting, JP-Y
Published in: J Immunol
May 15, 2011

Long-lived humoral immune responses depend upon the generation of memory B cells and long-lived plasma cells during the germinal center (GC) reaction. These memory compartments, characterized by class-switched IgG and high-affinity Abs, are the basis for successful vaccination. We report that a new member of the plexin family of molecules, plexin-D1, controls the GC reaction and is required for secondary humoral immune responses. Plexin-D1 was not required for B cell maturation, marginal zone precursor development, dark and light zone formation, Igλ(+) and Igκ(+) B cell skewing, B1/B2 development, and the initial extrafollicular response. Plexin-D1 expression was increased following B cell activation, and PlxnD1(-/-) mice exhibited defective GC reactions during T-dependent immune activation. PlxnD1(-/-) B cells showed a defect in migration toward the GC chemokines, CXCL12, CXCL13, and CCL19. Accordingly, PlxnD1(-/-) mice exhibited defective production of IgG1 and IgG2b, but not IgG3 serum Ab, accompanied by reductions in long-lived bone marrow plasmacytes and recall humoral memory responses. These data show a new role for immune plexins in the GC reaction and generation of immunologic memory.

Duke Scholars

Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

May 15, 2011

Volume

186

Issue

10

Start / End Page

5603 / 5611

Location

United States

Related Subject Headings

  • Plasma Cells
  • Nerve Tissue Proteins
  • Mice, Transgenic
  • Mice, Inbred C57BL
  • Mice
  • Membrane Glycoproteins
  • Lymphocyte Activation
  • Intracellular Signaling Peptides and Proteins
  • Immunology
  • Immunologic Memory
 

Citation

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Holl, E. K., O’Connor, B. P., Holl, T. M., Roney, K. E., Zimmermann, A. G., Jha, S., … Ting, J.-Y. (2011). Plexin-D1 is a novel regulator of germinal centers and humoral immune responses. J Immunol, 186(10), 5603–5611. https://doi.org/10.4049/jimmunol.1003464
Holl, Eda K., Brian P. O’Connor, T Matt Holl, Kelly E. Roney, Albert G. Zimmermann, Sushmita Jha, Garnett Kelsoe, and Jenny P-Y Ting. “Plexin-D1 is a novel regulator of germinal centers and humoral immune responses.J Immunol 186, no. 10 (May 15, 2011): 5603–11. https://doi.org/10.4049/jimmunol.1003464.
Holl EK, O’Connor BP, Holl TM, Roney KE, Zimmermann AG, Jha S, et al. Plexin-D1 is a novel regulator of germinal centers and humoral immune responses. J Immunol. 2011 May 15;186(10):5603–11.
Holl, Eda K., et al. “Plexin-D1 is a novel regulator of germinal centers and humoral immune responses.J Immunol, vol. 186, no. 10, May 2011, pp. 5603–11. Pubmed, doi:10.4049/jimmunol.1003464.
Holl EK, O’Connor BP, Holl TM, Roney KE, Zimmermann AG, Jha S, Kelsoe G, Ting JP-Y. Plexin-D1 is a novel regulator of germinal centers and humoral immune responses. J Immunol. 2011 May 15;186(10):5603–5611.

Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

May 15, 2011

Volume

186

Issue

10

Start / End Page

5603 / 5611

Location

United States

Related Subject Headings

  • Plasma Cells
  • Nerve Tissue Proteins
  • Mice, Transgenic
  • Mice, Inbred C57BL
  • Mice
  • Membrane Glycoproteins
  • Lymphocyte Activation
  • Intracellular Signaling Peptides and Proteins
  • Immunology
  • Immunologic Memory