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Apoptosis and cytokines in non-alcoholic steatohepatitis.

Publication ,  Journal Article
Syn, W-K; Choi, SS; Diehl, AM
Published in: Clin Liver Dis
November 2009

Non-alcoholic fatty liver disease (NAFLD), one of the commonest causes of chronic liver disease in the United States, represents several overlapping clinicopathological states, ranging from simple steatosis to non-alcoholic steatohepatitis (NASH). Although dysregulated lipid accumulation occurs across the spectrum of NAFLD, features of liver cell injury, such as hepatocyte ballooning, cytoskeletal changes (Mallory-Denk bodies), and hepatocyte apoptosis, occur predominantly in NASH and distinguish NASH from simple steatosis. Indeed, NASH is a more serious form of liver damage because cirrhosis and hepatocellular carcinoma are potential outcomes of NASH. Meanwhile, cirrhosis and hepatocellular carcinoma rarely occur in individuals with simple steatosis. Hepatic injury and apoptosis that occur in adults are often dysregulated and accompanied by the accumulation of immune cells, which produce cytokines and growth factors that drive chronic inflammation and may result in fibrosis. This article summarizes the process of apoptosis and roles of putative cytokines in progressive NAFLD.

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Published In

Clin Liver Dis

DOI

EISSN

1557-8224

Publication Date

November 2009

Volume

13

Issue

4

Start / End Page

565 / 580

Location

United States

Related Subject Headings

  • Liver Neoplasms
  • Liver Cirrhosis
  • Humans
  • Hepatocytes
  • Gastroenterology & Hepatology
  • Fatty Liver
  • Cytokines
  • Carcinoma, Hepatocellular
  • Apoptosis
  • Adult
 

Citation

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Chicago
ICMJE
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Syn, W.-K., Choi, S. S., & Diehl, A. M. (2009). Apoptosis and cytokines in non-alcoholic steatohepatitis. Clin Liver Dis, 13(4), 565–580. https://doi.org/10.1016/j.cld.2009.07.003
Syn, Wing-Kin, Steve S. Choi, and Anna Mae Diehl. “Apoptosis and cytokines in non-alcoholic steatohepatitis.Clin Liver Dis 13, no. 4 (November 2009): 565–80. https://doi.org/10.1016/j.cld.2009.07.003.
Syn W-K, Choi SS, Diehl AM. Apoptosis and cytokines in non-alcoholic steatohepatitis. Clin Liver Dis. 2009 Nov;13(4):565–80.
Syn, Wing-Kin, et al. “Apoptosis and cytokines in non-alcoholic steatohepatitis.Clin Liver Dis, vol. 13, no. 4, Nov. 2009, pp. 565–80. Pubmed, doi:10.1016/j.cld.2009.07.003.
Syn W-K, Choi SS, Diehl AM. Apoptosis and cytokines in non-alcoholic steatohepatitis. Clin Liver Dis. 2009 Nov;13(4):565–580.
Journal cover image

Published In

Clin Liver Dis

DOI

EISSN

1557-8224

Publication Date

November 2009

Volume

13

Issue

4

Start / End Page

565 / 580

Location

United States

Related Subject Headings

  • Liver Neoplasms
  • Liver Cirrhosis
  • Humans
  • Hepatocytes
  • Gastroenterology & Hepatology
  • Fatty Liver
  • Cytokines
  • Carcinoma, Hepatocellular
  • Apoptosis
  • Adult