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Pairing QuantiFERON gold in-tube with opt-out HIV testing in a tuberculosis contact investigation in the Southeastern United States.

Publication ,  Journal Article
Person, AK; Goswami, ND; Bissette, DJ; Turner, DS; Baker, AV; Gadkowski, LB; Naggie, S; Erlandson, K; Chen, L; Lalani, T; Cox, GM; Stout, JE
Published in: AIDS Patient Care STDS
September 2010

Knowing one's HIV status is particularly important in the setting of recent tuberculosis (TB) exposure. Blood tests for assessment of tuberculosis infection, such as the QuantiFERON Gold in-tube test (QFT; Cellestis Limited, Carnegie, Victoria, Australia), offer the possibility of simultaneous screening for TB and HIV with a single blood draw. We performed a cross-sectional analysis of all contacts to a highly infectious TB case in a large meatpacking factory. Twenty-two percent were foreign-born and 73% were black. Contacts were tested with both tuberculin skin testing (TST) and QFT. HIV testing was offered on an opt-out basis. Persons with TST >or=10 mm, positive QFT, and/or positive HIV test were offered latent TB treatment. Three hundred twenty-six contacts were screened: TST results were available for 266 people and an additional 24 reported a prior positive TST for a total of 290 persons with any TST result (89.0%). Adequate QFT specimens were obtained for 312 (95.7%) of persons. Thirty-two persons had QFT results but did not return for TST reading. Twenty-two percent met the criteria for latent TB infection. Eighty-eight percent accepted HIV testing. Two (0.7%) were HIV seropositive; both individuals were already aware of their HIV status, but one had stopped care a year previously. None of the HIV-seropositive persons had latent TB, but all were offered latent TB treatment per standard guidelines. This demonstrates that opt-out HIV testing combined with QFT in a large TB contact investigation was feasible and useful. HIV testing was also widely accepted. Pairing QFT with opt-out HIV testing should be strongly considered when possible.

Duke Scholars

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Published In

AIDS Patient Care STDS

DOI

EISSN

1557-7449

Publication Date

September 2010

Volume

24

Issue

9

Start / End Page

539 / 543

Location

United States

Related Subject Headings

  • Young Adult
  • Virology
  • Viral Load
  • Tuberculosis, Pulmonary
  • Tuberculin Test
  • Southeastern United States
  • Retrospective Studies
  • Mycobacterium tuberculosis
  • Middle Aged
  • Male
 

Citation

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Chicago
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Person, A. K., Goswami, N. D., Bissette, D. J., Turner, D. S., Baker, A. V., Gadkowski, L. B., … Stout, J. E. (2010). Pairing QuantiFERON gold in-tube with opt-out HIV testing in a tuberculosis contact investigation in the Southeastern United States. AIDS Patient Care STDS, 24(9), 539–543. https://doi.org/10.1089/apc.2010.0102
Person, Anna K., Neela D. Goswami, Deborah J. Bissette, Debra S. Turner, Ann V. Baker, L Beth Gadkowski, Susanna Naggie, et al. “Pairing QuantiFERON gold in-tube with opt-out HIV testing in a tuberculosis contact investigation in the Southeastern United States.AIDS Patient Care STDS 24, no. 9 (September 2010): 539–43. https://doi.org/10.1089/apc.2010.0102.
Person AK, Goswami ND, Bissette DJ, Turner DS, Baker AV, Gadkowski LB, et al. Pairing QuantiFERON gold in-tube with opt-out HIV testing in a tuberculosis contact investigation in the Southeastern United States. AIDS Patient Care STDS. 2010 Sep;24(9):539–43.
Person, Anna K., et al. “Pairing QuantiFERON gold in-tube with opt-out HIV testing in a tuberculosis contact investigation in the Southeastern United States.AIDS Patient Care STDS, vol. 24, no. 9, Sept. 2010, pp. 539–43. Pubmed, doi:10.1089/apc.2010.0102.
Person AK, Goswami ND, Bissette DJ, Turner DS, Baker AV, Gadkowski LB, Naggie S, Erlandson K, Chen L, Lalani T, Cox GM, Stout JE. Pairing QuantiFERON gold in-tube with opt-out HIV testing in a tuberculosis contact investigation in the Southeastern United States. AIDS Patient Care STDS. 2010 Sep;24(9):539–543.
Journal cover image

Published In

AIDS Patient Care STDS

DOI

EISSN

1557-7449

Publication Date

September 2010

Volume

24

Issue

9

Start / End Page

539 / 543

Location

United States

Related Subject Headings

  • Young Adult
  • Virology
  • Viral Load
  • Tuberculosis, Pulmonary
  • Tuberculin Test
  • Southeastern United States
  • Retrospective Studies
  • Mycobacterium tuberculosis
  • Middle Aged
  • Male