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Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C.

Publication ,  Journal Article
Tillmann, HL; Patel, K; Muir, AJ; Guy, CD; Li, JH; Lao, XQ; Thompson, A; Clark, PJ; Gardner, SD; McHutchison, JG; McCarthy, JJ
Published in: J Hepatol
December 2011

BACKGROUND & AIMS: IL28B polymorphisms have been associated with both treatment induced and spontaneous clearance of hepatitis C virus (HCV). We previously found that LDL cholesterol levels were higher in chronic hepatitis C (CHC) patients with the CC genotype at the rs12979860 polymorphism, located proximal to the IL28 gene. Here we analyzed the association of steatosis with IL28B genotype in treatment naïve patients with CHC. METHODS: Two independent cohorts of 145 genotype 1 infected patients from an antifibrotic study and 180 genotype 1 patients from Duke were analyzed for the presence and severity of steatosis in relation to the rs12979860 polymorphism at the IL28B locus. TaqMan assay based genotyping classified three groups CC, CT, and TT. RESULTS: CC genotype was associated with a lower prevalence of steatosis. In the antifibrotic study, steatosis was found in 47.6% (50/105) of IL28B non-CC vs. 22.5% (9/40; p=0.008) in CC patients. Similarly, steatosis was found in 67.4% (89/132) of non-CC patients compared to only 39.6% (19/48; p=0.001) of CC patients in the Duke cohort. CONCLUSIONS: IL28B CC genotype is associated with less pronounced disturbances of lipid metabolism, as reflected both in serum lipoprotein levels and hepatic steatosis, in HCV infection.

Duke Scholars

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Published In

J Hepatol

DOI

EISSN

1600-0641

Publication Date

December 2011

Volume

55

Issue

6

Start / End Page

1195 / 1200

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Male
  • Lipoproteins
  • Lipid Metabolism
  • Interleukins
  • Interferons
  • Humans
  • Hepatitis C, Chronic
 

Citation

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Tillmann, H. L., Patel, K., Muir, A. J., Guy, C. D., Li, J. H., Lao, X. Q., … McCarthy, J. J. (2011). Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C. J Hepatol, 55(6), 1195–1200. https://doi.org/10.1016/j.jhep.2011.03.015
Tillmann, Hans L., Keyur Patel, Andrew J. Muir, Cynthia D. Guy, Josephine H. Li, Xiang Qian Lao, Alexander Thompson, et al. “Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C.J Hepatol 55, no. 6 (December 2011): 1195–1200. https://doi.org/10.1016/j.jhep.2011.03.015.
Tillmann HL, Patel K, Muir AJ, Guy CD, Li JH, Lao XQ, et al. Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C. J Hepatol. 2011 Dec;55(6):1195–200.
Tillmann, Hans L., et al. “Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C.J Hepatol, vol. 55, no. 6, Dec. 2011, pp. 1195–200. Pubmed, doi:10.1016/j.jhep.2011.03.015.
Tillmann HL, Patel K, Muir AJ, Guy CD, Li JH, Lao XQ, Thompson A, Clark PJ, Gardner SD, McHutchison JG, McCarthy JJ. Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C. J Hepatol. 2011 Dec;55(6):1195–1200.
Journal cover image

Published In

J Hepatol

DOI

EISSN

1600-0641

Publication Date

December 2011

Volume

55

Issue

6

Start / End Page

1195 / 1200

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Male
  • Lipoproteins
  • Lipid Metabolism
  • Interleukins
  • Interferons
  • Humans
  • Hepatitis C, Chronic