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Comparison of time domain and frequency domain variables from the signal-averaged electrocardiogram: a multivariable analysis.

Publication ,  Journal Article
Worley, SJ; Mark, DB; Smith, WM; Wolf, P; Califf, RM; Strauss, HC; Manwaring, MG; Ideker, RE
Published in: J Am Coll Cardiol
May 1988

The relative values of the unprocessed signal-averaged electrocardiogram (ECG) and time domain analysis and frequency domain analysis of the signal-averaged ECG were compared in 36 patients with sustained monomorphic ventricular tachycardia and a remote myocardial infarction, in 29 asymptomatic patients with a remote myocardial infarction and in 23 normal subjects. Area ratios of the energy spectra derived from fast Fourier transform analysis were calculated using six separate 140 ms intervals starting at 0, 40, 50 and 60 ms after QRS onset; 40 and 50 ms before QRS end and a variable length interval starting 40 ms before QRS end and extending to the T wave. Total filtered QRS duration, late potential duration and root mean square voltage of the terminal QRS complex were measured from the filtered vector magnitude signal-averaged ECG. The total QRS duration was also measured from the X, Y, Z leads of the unfiltered signal-averaged ECG. Seven variables were significantly different in univariate tests between myocardial infarction patients with and without ventricular tachycardia: three fast Fourier transform area ratios with the sampling interval starting at 1) QRS onset (p = 0.007), 2) 40 ms after QRS onset (p = 0.02), and 3) 60 ms after QRS onset (p less than 0.0001); and all four time domain variables at 1) total filtered QRS duration (p less than 0.0001), 2) late potential duration (p = 0.0001), 3) root mean square terminal QRS voltage (p = 0.0001), and 4) QRS duration from the unprocessed signal-averaged ECG (p less than 0.0001). Of these seven variables, only the fast Fourier transform area ratio starting at QRS onset was significantly different between patients with myocardial infarction without ventricular tachycardia and normal subjects. In multi-variable analysis, the total filtered vector magnitude QRS duration, a time domain variable that includes the late potential, was the only independent factor that separated patients with myocardial infarction with and without associated ventricular tachycardia.

Duke Scholars

Published In

J Am Coll Cardiol

DOI

ISSN

0735-1097

Publication Date

May 1988

Volume

11

Issue

5

Start / End Page

1041 / 1051

Location

United States

Related Subject Headings

  • Time Factors
  • Tachycardia
  • Stroke Volume
  • Signal Processing, Computer-Assisted
  • Probability
  • Myocardial Infarction
  • Humans
  • Fourier Analysis
  • Electrocardiography
  • Diagnosis, Differential
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Worley, S. J., Mark, D. B., Smith, W. M., Wolf, P., Califf, R. M., Strauss, H. C., … Ideker, R. E. (1988). Comparison of time domain and frequency domain variables from the signal-averaged electrocardiogram: a multivariable analysis. J Am Coll Cardiol, 11(5), 1041–1051. https://doi.org/10.1016/s0735-1097(98)90064-x
Worley, S. J., D. B. Mark, W. M. Smith, P. Wolf, R. M. Califf, H. C. Strauss, M. G. Manwaring, and R. E. Ideker. “Comparison of time domain and frequency domain variables from the signal-averaged electrocardiogram: a multivariable analysis.J Am Coll Cardiol 11, no. 5 (May 1988): 1041–51. https://doi.org/10.1016/s0735-1097(98)90064-x.
Worley SJ, Mark DB, Smith WM, Wolf P, Califf RM, Strauss HC, et al. Comparison of time domain and frequency domain variables from the signal-averaged electrocardiogram: a multivariable analysis. J Am Coll Cardiol. 1988 May;11(5):1041–51.
Worley, S. J., et al. “Comparison of time domain and frequency domain variables from the signal-averaged electrocardiogram: a multivariable analysis.J Am Coll Cardiol, vol. 11, no. 5, May 1988, pp. 1041–51. Pubmed, doi:10.1016/s0735-1097(98)90064-x.
Worley SJ, Mark DB, Smith WM, Wolf P, Califf RM, Strauss HC, Manwaring MG, Ideker RE. Comparison of time domain and frequency domain variables from the signal-averaged electrocardiogram: a multivariable analysis. J Am Coll Cardiol. 1988 May;11(5):1041–1051.
Journal cover image

Published In

J Am Coll Cardiol

DOI

ISSN

0735-1097

Publication Date

May 1988

Volume

11

Issue

5

Start / End Page

1041 / 1051

Location

United States

Related Subject Headings

  • Time Factors
  • Tachycardia
  • Stroke Volume
  • Signal Processing, Computer-Assisted
  • Probability
  • Myocardial Infarction
  • Humans
  • Fourier Analysis
  • Electrocardiography
  • Diagnosis, Differential