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Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment.

Publication ,  Journal Article
Wang, Y; Challa, P; Epstein, DL; Yuan, F
Published in: Biomaterials
August 2004

Ethacrynic acid (ECA) is a potential glaucoma drug that can reduce intraocular pressure. However, conventional methods of ECA administration may cause toxicity to normal eye tissues and are inconvenient to patients. Therefore, we developed and characterized an ECA loaded poly(lactide-co-glycolide) (PLGA) copolymer film, and quantified the therapeutic efficacy of the film implanted in the rabbit eye. In the aqueous medium, the release of ECA from the PLGA50:50 film was time dependent and more than 90% of ECA was released within a week. This release profile was consistent with the kinetics of water uptake and microstructural changes of PLGA50:50 films as revealed by an electron microscopy examination. ECA release and PLGA degradation caused a gradual pH decrease in the release medium. The total pH decrease was 0.4 unit in 3 days. We also observed that the initial rate of ECA release was positively correlated with the weight ratio of ECA versus PLGA and inversely correlated with the molar ratio of lactide versus glycolide in PLGA films. At the end of a 3-day incubation, the cumulative release of ECA from PLGA50:50, PLGA85:15 and PLGA100:00 films were 78.8%, 9.35% and 3.60%, respectively. When the PLGA50:50 film loaded with ECA was implanted into the sclera of rabbit eyes, the intraocular pressure was significantly reduced and the reduction was maintained for at least 10 days. These data indicate that PLGA films have a potential to be used as a controlled ECA release device for glaucoma treatment.

Duke Scholars

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Published In

Biomaterials

DOI

ISSN

0142-9612

Publication Date

August 2004

Volume

25

Issue

18

Start / End Page

4279 / 4285

Location

Netherlands

Related Subject Headings

  • Water
  • Treatment Outcome
  • Surface Properties
  • Rabbits
  • Porosity
  • Polymers
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Polyglycolic Acid
  • Membranes, Artificial
  • Lactic Acid
 

Citation

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Wang, Y., Challa, P., Epstein, D. L., & Yuan, F. (2004). Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment. Biomaterials, 25(18), 4279–4285. https://doi.org/10.1016/j.biomaterials.2003.10.075
Wang, Yong, Pratap Challa, David L. Epstein, and Fan Yuan. “Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment.Biomaterials 25, no. 18 (August 2004): 4279–85. https://doi.org/10.1016/j.biomaterials.2003.10.075.
Wang Y, Challa P, Epstein DL, Yuan F. Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment. Biomaterials. 2004 Aug;25(18):4279–85.
Wang, Yong, et al. “Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment.Biomaterials, vol. 25, no. 18, Aug. 2004, pp. 4279–85. Pubmed, doi:10.1016/j.biomaterials.2003.10.075.
Wang Y, Challa P, Epstein DL, Yuan F. Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment. Biomaterials. 2004 Aug;25(18):4279–4285.

Published In

Biomaterials

DOI

ISSN

0142-9612

Publication Date

August 2004

Volume

25

Issue

18

Start / End Page

4279 / 4285

Location

Netherlands

Related Subject Headings

  • Water
  • Treatment Outcome
  • Surface Properties
  • Rabbits
  • Porosity
  • Polymers
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Polyglycolic Acid
  • Membranes, Artificial
  • Lactic Acid