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High expression of insulin-like growth factor binding protein-2 messenger RNA in epithelial ovarian cancers produces elevated preoperative serum levels.

Publication ,  Journal Article
Lancaster, JM; Sayer, RA; Blanchette, C; Calingaert, B; Konidari, I; Gray, J; Schildkraut, J; Schomberg, DW; Marks, JR; Berchuck, A
Published in: Int J Gynecol Cancer
2006

The molecular etiology of epithelial ovarian cancer remains unclear. Using microarray expression analysis, we recently reported that expression of the insulin-like growth factor binding protein-2 (IGFBP-2) gene is elevated in advanced epithelial ovarian cancers. The aim of this study was to further delineate the role of IGFBP-2 in the pathoetiology of epithelial ovarian cancer and determine if elevated ovarian cancer IGFBP-2 gene expression is reflected in serum. Relative IGFBP-2 expression was measured using quantitative real-time polymerase chain reaction in 113 epithelial ovarian cancers and 6 normal ovarian surface epithelial samples. Preoperative serum IGFBP-2 levels were measured by radioimmunoassay in 84 women (42 ovarian cancers, 26 benign gynecological conditions, and 10 healthy female controls). Ovarian cancers demonstrated 38-fold higher mean IGFBP-2 expression than normal ovarian epithelium (P < 0.01). Serum IGFBP-2 levels were elevated in women with early- and advanced-stage ovarian cancer compared to controls and patients with benign gynecological conditions (P = 0.05 and P < 0.01, respectively). Epithelial ovarian cancers express high levels of IGFBP-2 relative to normal ovarian epithelium, and this is associated with elevated serum IGFBP-2 levels compared to both normal controls and patients with benign gynecological disease. Our findings provide further support that the insulin-like growth factor pathway plays a significant role in epithelial ovarian cancer pathogenesis. Further, IGFBP-2 may represent an additional serum biomarker with utility in detection and monitoring of epithelial ovarian cancer.

Duke Scholars

Published In

Int J Gynecol Cancer

DOI

ISSN

1048-891X

Publication Date

2006

Volume

16

Issue

4

Start / End Page

1529 / 1535

Location

England

Related Subject Headings

  • Reverse Transcriptase Polymerase Chain Reaction
  • RNA, Messenger
  • Preoperative Care
  • Precancerous Conditions
  • Ovary
  • Ovarian Neoplasms
  • Ovarian Cysts
  • Oncology & Carcinogenesis
  • Neoplasms, Glandular and Epithelial
  • Neoplasm Staging
 

Citation

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MLA
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Lancaster, J. M., Sayer, R. A., Blanchette, C., Calingaert, B., Konidari, I., Gray, J., … Berchuck, A. (2006). High expression of insulin-like growth factor binding protein-2 messenger RNA in epithelial ovarian cancers produces elevated preoperative serum levels. Int J Gynecol Cancer, 16(4), 1529–1535. https://doi.org/10.1111/j.1525-1438.2006.00623.x
Lancaster, J. M., R. A. Sayer, C. Blanchette, B. Calingaert, I. Konidari, J. Gray, J. Schildkraut, D. W. Schomberg, J. R. Marks, and A. Berchuck. “High expression of insulin-like growth factor binding protein-2 messenger RNA in epithelial ovarian cancers produces elevated preoperative serum levels.Int J Gynecol Cancer 16, no. 4 (2006): 1529–35. https://doi.org/10.1111/j.1525-1438.2006.00623.x.
Lancaster JM, Sayer RA, Blanchette C, Calingaert B, Konidari I, Gray J, et al. High expression of insulin-like growth factor binding protein-2 messenger RNA in epithelial ovarian cancers produces elevated preoperative serum levels. Int J Gynecol Cancer. 2006;16(4):1529–35.
Lancaster, J. M., et al. “High expression of insulin-like growth factor binding protein-2 messenger RNA in epithelial ovarian cancers produces elevated preoperative serum levels.Int J Gynecol Cancer, vol. 16, no. 4, 2006, pp. 1529–35. Pubmed, doi:10.1111/j.1525-1438.2006.00623.x.
Lancaster JM, Sayer RA, Blanchette C, Calingaert B, Konidari I, Gray J, Schildkraut J, Schomberg DW, Marks JR, Berchuck A. High expression of insulin-like growth factor binding protein-2 messenger RNA in epithelial ovarian cancers produces elevated preoperative serum levels. Int J Gynecol Cancer. 2006;16(4):1529–1535.

Published In

Int J Gynecol Cancer

DOI

ISSN

1048-891X

Publication Date

2006

Volume

16

Issue

4

Start / End Page

1529 / 1535

Location

England

Related Subject Headings

  • Reverse Transcriptase Polymerase Chain Reaction
  • RNA, Messenger
  • Preoperative Care
  • Precancerous Conditions
  • Ovary
  • Ovarian Neoplasms
  • Ovarian Cysts
  • Oncology & Carcinogenesis
  • Neoplasms, Glandular and Epithelial
  • Neoplasm Staging