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MicroRNA processing and binding site polymorphisms are not replicated in the Ovarian Cancer Association Consortium.

Publication ,  Journal Article
Permuth-Wey, J; Chen, Z; Tsai, Y-Y; Lin, H-Y; Chen, YA; Barnholtz-Sloan, J; Birrer, MJ; Chanock, SJ; Cramer, DW; Cunningham, JM; Fridley, BL ...
Published in: Cancer Epidemiol Biomarkers Prev
August 2011

BACKGROUND: Single nucleotide polymorphisms (SNP) in microRNA-related genes have been associated with epithelial ovarian cancer (EOC) risk in two reports, yet associated alleles may be inconsistent across studies. METHODS: We conducted a pooled analysis of previously identified SNPs by combining genotype data from 3,973 invasive EOC cases and 3,276 controls from the Ovarian Cancer Association Consortium. We also conducted imputation to obtain dense coverage of genes and comparable genotype data for all studies. In total, 226 SNPs within 15 kb of 4 miRNA biogenesis genes (DDX20, DROSHA, GEMIN4, and XPO5) and 23 SNPs located within putative miRNA binding sites of 6 genes (CAV1, COL18A1, E2F2, IL1R1, KRAS, and UGT2A3) were genotyped or imputed and analyzed in the entire dataset. RESULTS: After adjustment for European ancestry, no overall association was observed between any of the analyzed SNPs and EOC risk. CONCLUSIONS: Common variants in these evaluated genes do not seem to be strongly associated with EOC risk. IMPACT: This analysis suggests earlier associations between EOC risk and SNPs in these genes may have been chance findings, possibly confounded by population admixture. To more adequately evaluate the relationship between genetic variants and cancer risk, large sample sizes are needed, adjustment for population stratification should be carried out, and use of imputed SNP data should be considered.

Duke Scholars

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

August 2011

Volume

20

Issue

8

Start / End Page

1793 / 1797

Location

United States

Related Subject Headings

  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Ovarian Neoplasms
  • Neoplasms, Glandular and Epithelial
  • MicroRNAs
  • Humans
  • Genotype
  • Genetic Predisposition to Disease
  • Female
  • Epidemiology
 

Citation

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Permuth-Wey, J., Chen, Z., Tsai, Y.-Y., Lin, H.-Y., Chen, Y. A., Barnholtz-Sloan, J., … Ovarian Cancer Association Consortium (OCAC). (2011). MicroRNA processing and binding site polymorphisms are not replicated in the Ovarian Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev, 20(8), 1793–1797. https://doi.org/10.1158/1055-9965.EPI-11-0397
Permuth-Wey, Jennifer, Zhihua Chen, Ya-Yu Tsai, Hui-Yi Lin, Y Ann Chen, Jill Barnholtz-Sloan, Michael J. Birrer, et al. “MicroRNA processing and binding site polymorphisms are not replicated in the Ovarian Cancer Association Consortium.Cancer Epidemiol Biomarkers Prev 20, no. 8 (August 2011): 1793–97. https://doi.org/10.1158/1055-9965.EPI-11-0397.
Permuth-Wey J, Chen Z, Tsai Y-Y, Lin H-Y, Chen YA, Barnholtz-Sloan J, et al. MicroRNA processing and binding site polymorphisms are not replicated in the Ovarian Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev. 2011 Aug;20(8):1793–7.
Permuth-Wey, Jennifer, et al. “MicroRNA processing and binding site polymorphisms are not replicated in the Ovarian Cancer Association Consortium.Cancer Epidemiol Biomarkers Prev, vol. 20, no. 8, Aug. 2011, pp. 1793–97. Pubmed, doi:10.1158/1055-9965.EPI-11-0397.
Permuth-Wey J, Chen Z, Tsai Y-Y, Lin H-Y, Chen YA, Barnholtz-Sloan J, Birrer MJ, Chanock SJ, Cramer DW, Cunningham JM, Fenstermacher D, Fridley BL, Garcia-Closas M, Gayther SA, Gentry-Maharaj A, Gonzalez-Bosquet J, Iversen E, Jim H, McLaughlin J, Menon U, Narod SA, Phelan CM, Ramus SJ, Risch H, Song H, Sutphen R, Terry KL, Tyrer J, Vierkant RA, Wentzensen N, Lancaster JM, Cheng JQ, Berchuck A, Pharoah PDP, Schildkraut JM, Goode EL, Sellers TA, Ovarian Cancer Association Consortium (OCAC). MicroRNA processing and binding site polymorphisms are not replicated in the Ovarian Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev. 2011 Aug;20(8):1793–1797.

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

August 2011

Volume

20

Issue

8

Start / End Page

1793 / 1797

Location

United States

Related Subject Headings

  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Ovarian Neoplasms
  • Neoplasms, Glandular and Epithelial
  • MicroRNAs
  • Humans
  • Genotype
  • Genetic Predisposition to Disease
  • Female
  • Epidemiology