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The long and the short of telomeres in bone marrow recipient SCID patients.

Publication ,  Journal Article
Sarzotti-Kelsoe, M; Daniell, XG; Whitesides, JF; Buckley, RH
Published in: Immunol Res
April 2011

Telomeres are noncoding DNA regions at the end of the chromosomes that are crucial for genome stability. Since telomere length decreases with cell division, they can be used as a signature of cell proliferation history. T-cell reconstitution in severe combined immunodeficiency (SCID) subjects, recipients of T-cell-depleted, allogeneic-related bone marrow cells, is due to the development and maturation of donor T-cell precursors in the infant's vestigial thymus and to homeostatic proliferation of mature T cells in the peripheral organs. Since T-cell function, thymic output, and T-cell clonal diversity are maintained long term in these patients, we investigated whether donor T-cell engraftment resulted in increased telomere shortening. Our study of seven SCID patients, following successful bone marrow transplantation, demonstrates that the patients' peripheral T cells did not exhibit greater than normal telomere shortening.

Duke Scholars

Published In

Immunol Res

DOI

EISSN

1559-0755

Publication Date

April 2011

Volume

49

Issue

1-3

Start / End Page

44 / 48

Location

United States

Related Subject Headings

  • Transplantation
  • Telomere
  • T-Lymphocytes
  • Severe Combined Immunodeficiency
  • Receptors, Antigen, T-Cell
  • Precursor Cells, T-Lymphoid
  • Immunology
  • Humans
  • Flow Cytometry
  • Cell Proliferation
 

Citation

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Sarzotti-Kelsoe, M., Daniell, X. G., Whitesides, J. F., & Buckley, R. H. (2011). The long and the short of telomeres in bone marrow recipient SCID patients. Immunol Res, 49(1–3), 44–48. https://doi.org/10.1007/s12026-010-8192-8
Sarzotti-Kelsoe, Marcella, Xiaoju G. Daniell, John F. Whitesides, and Rebecca H. Buckley. “The long and the short of telomeres in bone marrow recipient SCID patients.Immunol Res 49, no. 1–3 (April 2011): 44–48. https://doi.org/10.1007/s12026-010-8192-8.
Sarzotti-Kelsoe M, Daniell XG, Whitesides JF, Buckley RH. The long and the short of telomeres in bone marrow recipient SCID patients. Immunol Res. 2011 Apr;49(1–3):44–8.
Sarzotti-Kelsoe, Marcella, et al. “The long and the short of telomeres in bone marrow recipient SCID patients.Immunol Res, vol. 49, no. 1–3, Apr. 2011, pp. 44–48. Pubmed, doi:10.1007/s12026-010-8192-8.
Sarzotti-Kelsoe M, Daniell XG, Whitesides JF, Buckley RH. The long and the short of telomeres in bone marrow recipient SCID patients. Immunol Res. 2011 Apr;49(1–3):44–48.
Journal cover image

Published In

Immunol Res

DOI

EISSN

1559-0755

Publication Date

April 2011

Volume

49

Issue

1-3

Start / End Page

44 / 48

Location

United States

Related Subject Headings

  • Transplantation
  • Telomere
  • T-Lymphocytes
  • Severe Combined Immunodeficiency
  • Receptors, Antigen, T-Cell
  • Precursor Cells, T-Lymphoid
  • Immunology
  • Humans
  • Flow Cytometry
  • Cell Proliferation