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Long-term morbidities associated with vocal cord paralysis after surgical closure of a patent ductus arteriosus in extremely low birth weight infants.

Publication ,  Journal Article
Benjamin, JR; Smith, PB; Cotten, CM; Jaggers, J; Goldstein, RF; Malcolm, WF
Published in: J Perinatol
June 2010

OBJECTIVE: Determine associations between left vocal cord paralysis (LVCP) and poor respiratory, feeding and/or developmental outcomes in extremely low birth weight (ELBW) infants following surgical closure of a patent ductus arteriosus (PDA). STUDY DESIGN: ELBW infants who underwent PDA ligation between January 2004 and December 2006 were identified. We compared infants with and without LVCP following ligation to determine relationships between LVCP and respiratory morbidities, feeding and growth difficulties and neurodevelopmental impairment at 18 to 22-month follow-up. Student's t-test, Fisher's exact test and multivariable regression analyses were used to determine associations. RESULT: In all, 60 ELBW infants with a mean gestational age of 25 weeks and mean birth weight of 725 g had a PDA surgically closed. Twenty-two of 55 survivors (40%) were diagnosed with LVCP post-operatively. Infants with LVCP were significantly more likely to develop bronchopulmonary dysplasia (82 vs 39%, P=0.002), reactive airway disease (86 vs 33%, P<0.0001), or need for gastrostomy tube (63 vs 6%, P<0.0001). CONCLUSION: LVCP as a complication of surgical ductal ligation in ELBW infants is associated with persistent respiratory and feeding problems. Direct laryngoscopy should be considered for all infants who experience persistent respiratory and/or feeding difficulties following PDA ligation.

Duke Scholars

Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

June 2010

Volume

30

Issue

6

Start / End Page

408 / 413

Location

United States

Related Subject Headings

  • Vocal Cord Paralysis
  • Recurrent Laryngeal Nerve Injuries
  • Postoperative Complications
  • Pediatrics
  • Male
  • Ligation
  • Infant, Newborn
  • Infant, Extremely Low Birth Weight
  • Infant
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Benjamin, J. R., Smith, P. B., Cotten, C. M., Jaggers, J., Goldstein, R. F., & Malcolm, W. F. (2010). Long-term morbidities associated with vocal cord paralysis after surgical closure of a patent ductus arteriosus in extremely low birth weight infants. J Perinatol, 30(6), 408–413. https://doi.org/10.1038/jp.2009.124
Benjamin, J. R., P. B. Smith, C. M. Cotten, J. Jaggers, R. F. Goldstein, and W. F. Malcolm. “Long-term morbidities associated with vocal cord paralysis after surgical closure of a patent ductus arteriosus in extremely low birth weight infants.J Perinatol 30, no. 6 (June 2010): 408–13. https://doi.org/10.1038/jp.2009.124.
Benjamin JR, Smith PB, Cotten CM, Jaggers J, Goldstein RF, Malcolm WF. Long-term morbidities associated with vocal cord paralysis after surgical closure of a patent ductus arteriosus in extremely low birth weight infants. J Perinatol. 2010 Jun;30(6):408–13.
Benjamin, J. R., et al. “Long-term morbidities associated with vocal cord paralysis after surgical closure of a patent ductus arteriosus in extremely low birth weight infants.J Perinatol, vol. 30, no. 6, June 2010, pp. 408–13. Pubmed, doi:10.1038/jp.2009.124.
Benjamin JR, Smith PB, Cotten CM, Jaggers J, Goldstein RF, Malcolm WF. Long-term morbidities associated with vocal cord paralysis after surgical closure of a patent ductus arteriosus in extremely low birth weight infants. J Perinatol. 2010 Jun;30(6):408–413.

Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

June 2010

Volume

30

Issue

6

Start / End Page

408 / 413

Location

United States

Related Subject Headings

  • Vocal Cord Paralysis
  • Recurrent Laryngeal Nerve Injuries
  • Postoperative Complications
  • Pediatrics
  • Male
  • Ligation
  • Infant, Newborn
  • Infant, Extremely Low Birth Weight
  • Infant
  • Humans