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Assessment of physical functioning in recurrent glioma: preliminary comparison of performance status to functional capacity testing.

Publication ,  Journal Article
Jones, LW; Cohen, R-R; Mabe, SK; West, MJ; Desjardins, A; Vredenburgh, JJ; Friedman, AH; Reardon, DA; Waner, E; Friedman, HS
Published in: J Neurooncol
August 2009

BACKGROUND: Performance status (PS) scoring systems are tools of immense clinical importance in the management of patients with malignant disease but these tools are subjective and do not provide an objective evaluation of physical functioning. We conducted a pilot study to explore the feasibility and clinical utility of functional capacity testing to assess physical functioning in recurrent primary malignant glioma patients. PATIENTS AND METHODS: Using a cross-sectional design, consecutive patients with recurrent glioma performed a six minute walk (6MW) test to assess functional capacity. Performance status was assessed using Karnofsky Performance Status (KPS) scoring system. QOL was assessed by the Functional Assessment of Cancer Therapy-Brain scale. Self-reported exercise behavior was assessed using the Godin Leisure Time Exercise Questionnaire (GLTEQ). RESULTS: A total of 171 patients were recruited and tested. Seventy percent were diagnosed with glioblastoma multiforme (WHO grade IV) and 85% were undergoing therapy. Median KPS was 90% (range, 70-100%). Median 6MW distance was 400 m (range, 102-630 m), equivalent to 56 +/- 13% (range, 14-87%) of that predicted for age and sex. KPS, self-reported exercise, and QOL increased across 6MW distance quartiles (P < 0.05) although there was considerable variation within each category. 6MW distance and KPS were significantly correlated with each other (r = 0.34, P < 0.01) and several QOL domains (range, r = -0.43 to 0.46, P < 0.05). CONCLUSIONS: 6MW distance is a clinically feasible tool that provides an objective measure of physical functioning in select patients with recurrent glioma. Further research is required to investigate the prognostic value of these tests in patients with advanced malignancy.

Duke Scholars

Published In

J Neurooncol

DOI

EISSN

1573-7373

Publication Date

August 2009

Volume

94

Issue

1

Start / End Page

79 / 85

Location

United States

Related Subject Headings

  • Young Adult
  • Retrospective Studies
  • Recurrence
  • Quality of Life
  • Oncology & Carcinogenesis
  • Motor Activity
  • Middle Aged
  • Male
  • Karnofsky Performance Status
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Jones, L. W., Cohen, R.-R., Mabe, S. K., West, M. J., Desjardins, A., Vredenburgh, J. J., … Friedman, H. S. (2009). Assessment of physical functioning in recurrent glioma: preliminary comparison of performance status to functional capacity testing. J Neurooncol, 94(1), 79–85. https://doi.org/10.1007/s11060-009-9803-x
Jones, Lee W., Rachel-Rose Cohen, Stephanie K. Mabe, Miranda J. West, Annick Desjardins, James J. Vredenburgh, Allan H. Friedman, David A. Reardon, Emily Waner, and Henry S. Friedman. “Assessment of physical functioning in recurrent glioma: preliminary comparison of performance status to functional capacity testing.J Neurooncol 94, no. 1 (August 2009): 79–85. https://doi.org/10.1007/s11060-009-9803-x.
Jones LW, Cohen R-R, Mabe SK, West MJ, Desjardins A, Vredenburgh JJ, et al. Assessment of physical functioning in recurrent glioma: preliminary comparison of performance status to functional capacity testing. J Neurooncol. 2009 Aug;94(1):79–85.
Jones, Lee W., et al. “Assessment of physical functioning in recurrent glioma: preliminary comparison of performance status to functional capacity testing.J Neurooncol, vol. 94, no. 1, Aug. 2009, pp. 79–85. Pubmed, doi:10.1007/s11060-009-9803-x.
Jones LW, Cohen R-R, Mabe SK, West MJ, Desjardins A, Vredenburgh JJ, Friedman AH, Reardon DA, Waner E, Friedman HS. Assessment of physical functioning in recurrent glioma: preliminary comparison of performance status to functional capacity testing. J Neurooncol. 2009 Aug;94(1):79–85.
Journal cover image

Published In

J Neurooncol

DOI

EISSN

1573-7373

Publication Date

August 2009

Volume

94

Issue

1

Start / End Page

79 / 85

Location

United States

Related Subject Headings

  • Young Adult
  • Retrospective Studies
  • Recurrence
  • Quality of Life
  • Oncology & Carcinogenesis
  • Motor Activity
  • Middle Aged
  • Male
  • Karnofsky Performance Status
  • Humans