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Exercise behavior, functional capacity, and survival in adults with malignant recurrent glioma.

Publication ,  Journal Article
Ruden, E; Reardon, DA; Coan, AD; Herndon, JE; Hornsby, WE; West, M; Fels, DR; Desjardins, A; Vredenburgh, JJ; Waner, E; Friedman, AH ...
Published in: J Clin Oncol
July 20, 2011

PURPOSE: Identifying strong markers of prognosis are critical to optimize treatment and survival outcomes in patients with malignant recurrent glioma. We investigated the prognostic significance of exercise behavior and functional capacity in this population. PATIENTS AND METHODS: Using a prospective design, 243 patients with WHO grades 3 to 4 recurrent malignant glioma and Karnofsky performance status (KPS) ≥ 70 completed a self-administered questionnaire that assessed exercise behavior and performed a 6-minute walk test (6MWT) to assess functional capacity. Cox proportional models were used to estimate the risk of all-cause mortality according to 6MWT distance (6MWD; < 390 meters, 390-489 meters, > 489 meters) and exercise behavior (metabolic equivalent [MET] -h/wk) adjusted for KPS and other important clinical factors. RESULTS: Median follow-up was 27.43 months. During this period, 149 deaths were recorded (61% of the total sample). Exercise behavior was an independent predictor of survival (P = .0081). Median survival was 13.03 months for patients reporting < 9 MET-h/wk relative to 21.84 months for those reporting ≥ 9 MET-h/wk. Exercise behavior added incremental prognostic value beyond that provided by KPS, age, sex, grade, and number of prior progressions (P < .001). Compared with patients reporting < 9 MET-h/wk, the adjusted hazard ratio for mortality was 0.64 (95% CI, 0.46 to 0.91) for patients reporting ≥ 9 MET-h/wk. Functional capacity was not an independent predictor of prognosis. CONCLUSION: Exercise behavior is a strong independent predictor of survival that provides incremental prognostic value to KPS as well as traditional markers of prognosis in malignant recurrent glioma.

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Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

July 20, 2011

Volume

29

Issue

21

Start / End Page

2918 / 2923

Location

United States

Related Subject Headings

  • Walking
  • Treatment Outcome
  • Time Factors
  • Survival Rate
  • Survival Analysis
  • Surveys and Questionnaires
  • Risk Factors
  • Risk Assessment
  • Prospective Studies
  • Proportional Hazards Models
 

Citation

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Ruden, E., Reardon, D. A., Coan, A. D., Herndon, J. E., Hornsby, W. E., West, M., … Jones, L. W. (2011). Exercise behavior, functional capacity, and survival in adults with malignant recurrent glioma. J Clin Oncol, 29(21), 2918–2923. https://doi.org/10.1200/JCO.2011.34.9852
Ruden, Emily, David A. Reardon, April D. Coan, James E. Herndon, Whitney E. Hornsby, Miranda West, Diane R. Fels, et al. “Exercise behavior, functional capacity, and survival in adults with malignant recurrent glioma.J Clin Oncol 29, no. 21 (July 20, 2011): 2918–23. https://doi.org/10.1200/JCO.2011.34.9852.
Ruden E, Reardon DA, Coan AD, Herndon JE, Hornsby WE, West M, et al. Exercise behavior, functional capacity, and survival in adults with malignant recurrent glioma. J Clin Oncol. 2011 Jul 20;29(21):2918–23.
Ruden, Emily, et al. “Exercise behavior, functional capacity, and survival in adults with malignant recurrent glioma.J Clin Oncol, vol. 29, no. 21, July 2011, pp. 2918–23. Pubmed, doi:10.1200/JCO.2011.34.9852.
Ruden E, Reardon DA, Coan AD, Herndon JE, Hornsby WE, West M, Fels DR, Desjardins A, Vredenburgh JJ, Waner E, Friedman AH, Friedman HS, Peters KB, Jones LW. Exercise behavior, functional capacity, and survival in adults with malignant recurrent glioma. J Clin Oncol. 2011 Jul 20;29(21):2918–2923.

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

July 20, 2011

Volume

29

Issue

21

Start / End Page

2918 / 2923

Location

United States

Related Subject Headings

  • Walking
  • Treatment Outcome
  • Time Factors
  • Survival Rate
  • Survival Analysis
  • Surveys and Questionnaires
  • Risk Factors
  • Risk Assessment
  • Prospective Studies
  • Proportional Hazards Models