Hemodynamics as surrogate end points for survival in advanced heart failure: an analysis from FIRST.
Publication
, Journal Article
Shah, MR; Stinnett, SS; McNulty, SE; Gheorghiade, M; Zannad, F; Uretsky, B; Adams, KF; Califf, RM; O'connor, CM
Published in: Am Heart J
June 2001
BACKGROUND: Hemodynamics often are used as surrogate end points in phase II trials of acute heart failure (HF). We reviewed the Flolan International Randomized Survival Trial (FIRST) database to identify the hemodynamic variables that best predict survival in patients with advanced HF receiving epoprostenol therapy and to determine whether hemodynamics could predict the overall effect of a drug. METHODS: The trial enrolled 471 patients with class IIIb/IV HF and ejection fraction
Duke Scholars
Published In
Am Heart J
DOI
ISSN
0002-8703
Publication Date
June 2001
Volume
141
Issue
6
Start / End Page
908 / 914
Location
United States
Related Subject Headings
- Survival Analysis
- Randomized Controlled Trials as Topic
- Pulmonary Wedge Pressure
- Proportional Hazards Models
- Predictive Value of Tests
- Middle Aged
- Male
- Humans
- Hemodynamics
- Heart Failure
Citation
APA
Chicago
ICMJE
MLA
NLM
Shah, M. R., Stinnett, S. S., McNulty, S. E., Gheorghiade, M., Zannad, F., Uretsky, B., … O’connor, C. M. (2001). Hemodynamics as surrogate end points for survival in advanced heart failure: an analysis from FIRST. Am Heart J, 141(6), 908–914. https://doi.org/10.1067/mhj.2001.115299
Shah, M. R., S. S. Stinnett, S. E. McNulty, M. Gheorghiade, F. Zannad, B. Uretsky, K. F. Adams, R. M. Califf, and C. M. O’connor. “Hemodynamics as surrogate end points for survival in advanced heart failure: an analysis from FIRST.” Am Heart J 141, no. 6 (June 2001): 908–14. https://doi.org/10.1067/mhj.2001.115299.
Shah MR, Stinnett SS, McNulty SE, Gheorghiade M, Zannad F, Uretsky B, et al. Hemodynamics as surrogate end points for survival in advanced heart failure: an analysis from FIRST. Am Heart J. 2001 Jun;141(6):908–14.
Shah, M. R., et al. “Hemodynamics as surrogate end points for survival in advanced heart failure: an analysis from FIRST.” Am Heart J, vol. 141, no. 6, June 2001, pp. 908–14. Pubmed, doi:10.1067/mhj.2001.115299.
Shah MR, Stinnett SS, McNulty SE, Gheorghiade M, Zannad F, Uretsky B, Adams KF, Califf RM, O’connor CM. Hemodynamics as surrogate end points for survival in advanced heart failure: an analysis from FIRST. Am Heart J. 2001 Jun;141(6):908–914.
Published In
Am Heart J
DOI
ISSN
0002-8703
Publication Date
June 2001
Volume
141
Issue
6
Start / End Page
908 / 914
Location
United States
Related Subject Headings
- Survival Analysis
- Randomized Controlled Trials as Topic
- Pulmonary Wedge Pressure
- Proportional Hazards Models
- Predictive Value of Tests
- Middle Aged
- Male
- Humans
- Hemodynamics
- Heart Failure