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Outcomes by race and etiology of patients with left ventricular systolic dysfunction.

Publication ,  Journal Article
Thomas, KL; East, MA; Velazquez, EJ; Tuttle, RH; Shaw, LK; O'Connor, CM; Peterson, ED
Published in: Am J Cardiol
October 1, 2005

Previous studies have shown that blacks have worse long-term outcomes than whites who have systolic heart failure. The reasons for these racial differences remain unclear. We investigated the effect of race and etiology of heart failure on outcomes of patients who had left ventricular (LV) systolic dysfunction. We studied records of 1,977 patients (27% black) who underwent cardiac catheterization who had New York Heart Association class II to IV symptoms and a LV ejection fraction <40%. Adjusted Cox's proportional hazards regression models were examined for the end points of mortality, rehospitalization, and a composite of the 2. Black versus white patients were younger (median age 56 vs 63 years, p <0.01), more often were women (49% vs 33%, p <0.01), had diabetes (37% vs 31%, p = 0.02), and hypertension (75% vs 56%, p <0.01). Black patients were less likely to have significant coronary artery disease by angiography (41% vs 69%, p <0.01). Race was not an independent predictor of mortality (hazard ratio 1.09, 95% confidence interval 0.93 to 1.28, p = 0.27). After adjusted survival curves were stratified by race and etiology, the estimates indicated that among those patients who had nonischemic LV dysfunction, blacks appeared to have worse survival than whites. Thus, we found no racial differences in the long-term mortality risk of patients who had symptomatic LV systolic dysfunction. In conclusion, after stratifying by ischemic and nonischemic etiologies, we found decreased survival in blacks who had a nonischemic etiology compared with whites. There were no racial differences in rehospitalization between patients who had ischemic LV systolic dysfunction and those who did not.

Duke Scholars

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

October 1, 2005

Volume

96

Issue

7

Start / End Page

956 / 963

Location

United States

Related Subject Headings

  • White People
  • Ventricular Dysfunction, Left
  • United States
  • Treatment Outcome
  • Systole
  • Survival Rate
  • Stroke Volume
  • Risk Factors
  • Middle Aged
  • Male
 

Citation

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ICMJE
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Thomas, K. L., East, M. A., Velazquez, E. J., Tuttle, R. H., Shaw, L. K., O’Connor, C. M., & Peterson, E. D. (2005). Outcomes by race and etiology of patients with left ventricular systolic dysfunction. Am J Cardiol, 96(7), 956–963. https://doi.org/10.1016/j.amjcard.2005.07.002
Thomas, Kevin L., Mark A. East, Eric J. Velazquez, Robert H. Tuttle, Linda K. Shaw, Christopher M. O’Connor, and Eric D. Peterson. “Outcomes by race and etiology of patients with left ventricular systolic dysfunction.Am J Cardiol 96, no. 7 (October 1, 2005): 956–63. https://doi.org/10.1016/j.amjcard.2005.07.002.
Thomas KL, East MA, Velazquez EJ, Tuttle RH, Shaw LK, O’Connor CM, et al. Outcomes by race and etiology of patients with left ventricular systolic dysfunction. Am J Cardiol. 2005 Oct 1;96(7):956–63.
Thomas, Kevin L., et al. “Outcomes by race and etiology of patients with left ventricular systolic dysfunction.Am J Cardiol, vol. 96, no. 7, Oct. 2005, pp. 956–63. Pubmed, doi:10.1016/j.amjcard.2005.07.002.
Thomas KL, East MA, Velazquez EJ, Tuttle RH, Shaw LK, O’Connor CM, Peterson ED. Outcomes by race and etiology of patients with left ventricular systolic dysfunction. Am J Cardiol. 2005 Oct 1;96(7):956–963.
Journal cover image

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

October 1, 2005

Volume

96

Issue

7

Start / End Page

956 / 963

Location

United States

Related Subject Headings

  • White People
  • Ventricular Dysfunction, Left
  • United States
  • Treatment Outcome
  • Systole
  • Survival Rate
  • Stroke Volume
  • Risk Factors
  • Middle Aged
  • Male