Phase II study of Gleevec plus hydroxyurea in adults with progressive or recurrent low-grade glioma.
BACKGROUND: We evaluated the efficacy of imatinib plus hydroxyurea in patients with progressive/recurrent low-grade glioma. METHODS: A total of 64 patients with recurrent/progressive low-grade glioma were enrolled in this single-center study that stratified patients into astrocytoma and oligodendroglioma cohorts. All patients received 500 mg of hydroxyurea twice a day. Imatinib was administered at 400 mg per day for patients not on enzyme-inducing antiepileptic drugs (EIAEDs) and at 500 mg twice a day if on EIAEDs. The primary endpoint was progression-free survival at 12 months (PFS-12) and secondary endpoints were safety, median progression-free survival, and radiographic response rate. RESULTS: Thirty-two patients were enrolled into each cohort. Eleven patients (17%) had before radiotherapy and 24 (38%) had received before chemotherapy. The median PFS and PFS-12 were 11 months and 39%, respectively. Outcome did not differ between the histologic cohorts. No patient achieved a radiographic response. The most common grade 3 or greater adverse events were neutropenia (11%), thrombocytopenia (3%), and diarrhea (3%). CONCLUSIONS: Imatinib plus hydroxyurea was well tolerated among recurrent/progressive LGG patients but this regimen demonstrated negligible antitumor activity.
Duke Scholars
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Related Subject Headings
- Treatment Outcome
- Thrombocytopenia
- Temozolomide
- Pyrimidines
- Piperazines
- Oncology & Carcinogenesis
- Oligodendroglioma
- Neutropenia
- Neoplasm Recurrence, Local
- Middle Aged
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Treatment Outcome
- Thrombocytopenia
- Temozolomide
- Pyrimidines
- Piperazines
- Oncology & Carcinogenesis
- Oligodendroglioma
- Neutropenia
- Neoplasm Recurrence, Local
- Middle Aged