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BRCA1 mutations in primary breast and ovarian carcinomas.

Publication ,  Journal Article
Futreal, PA; Liu, Q; Shattuck-Eidens, D; Cochran, C; Harshman, K; Tavtigian, S; Bennett, LM; Haugen-Strano, A; Swensen, J; Miki, Y
Published in: Science
October 7, 1994

Loss of heterozygosity data from familial tumors suggest that BRCA1, a gene that confers susceptibility to ovarian and early-onset breast cancer, encodes a tumor suppressor. The BRCA1 region is also subject to allelic loss in sporadic breast and ovarian cancers, an indication that BRCA1 mutations may occur somatically in these tumors. The BRCA1 coding region was examined for mutations in primary breast and ovarian tumors that show allele loss at the BRCA1 locus. Mutations were detected in 3 of 32 breast and 1 of 12 ovarian carcinomas; all four mutations were germline alterations and occurred in early-onset cancers. These results suggest that mutation of BRCA1 may not be critical in the development of the majority of breast and ovarian cancers that arise in the absence of a mutant germline allele.

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Published In

Science

DOI

ISSN

0036-8075

Publication Date

October 7, 1994

Volume

266

Issue

5182

Start / End Page

120 / 122

Location

United States

Related Subject Headings

  • Transcription Factors
  • Ovarian Neoplasms
  • Neoplasm Proteins
  • Molecular Sequence Data
  • Middle Aged
  • Humans
  • Heterozygote
  • Germ-Line Mutation
  • Genetic Predisposition to Disease
  • Genes, Tumor Suppressor
 

Citation

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Futreal, P. A., Liu, Q., Shattuck-Eidens, D., Cochran, C., Harshman, K., Tavtigian, S., … Miki, Y. (1994). BRCA1 mutations in primary breast and ovarian carcinomas. Science, 266(5182), 120–122. https://doi.org/10.1126/science.7939630
Futreal, P. A., Q. Liu, D. Shattuck-Eidens, C. Cochran, K. Harshman, S. Tavtigian, L. M. Bennett, A. Haugen-Strano, J. Swensen, and Y. Miki. “BRCA1 mutations in primary breast and ovarian carcinomas.Science 266, no. 5182 (October 7, 1994): 120–22. https://doi.org/10.1126/science.7939630.
Futreal PA, Liu Q, Shattuck-Eidens D, Cochran C, Harshman K, Tavtigian S, et al. BRCA1 mutations in primary breast and ovarian carcinomas. Science. 1994 Oct 7;266(5182):120–2.
Futreal, P. A., et al. “BRCA1 mutations in primary breast and ovarian carcinomas.Science, vol. 266, no. 5182, Oct. 1994, pp. 120–22. Pubmed, doi:10.1126/science.7939630.
Futreal PA, Liu Q, Shattuck-Eidens D, Cochran C, Harshman K, Tavtigian S, Bennett LM, Haugen-Strano A, Swensen J, Miki Y. BRCA1 mutations in primary breast and ovarian carcinomas. Science. 1994 Oct 7;266(5182):120–122.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

October 7, 1994

Volume

266

Issue

5182

Start / End Page

120 / 122

Location

United States

Related Subject Headings

  • Transcription Factors
  • Ovarian Neoplasms
  • Neoplasm Proteins
  • Molecular Sequence Data
  • Middle Aged
  • Humans
  • Heterozygote
  • Germ-Line Mutation
  • Genetic Predisposition to Disease
  • Genes, Tumor Suppressor