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Human genetic susceptibility to Candida infections.

Publication ,  Journal Article
Plantinga, TS; Johnson, MD; Scott, WK; Joosten, LAB; van der Meer, JWM; Perfect, JR; Kullberg, BJ; Netea, MG
Published in: Med Mycol
November 2012

Infections with Candida spp. have different manifestations in humans, ranging from mucosal to bloodstream and deep-seated disseminated infections. Immunocompromised patients have increased susceptibility to these types of infections, due to reduced capacity to elicit effective innate or adaptive immunity. In addition, rare and common genetic variants in the human genome have been identified that influence susceptibility to Candida infections. Genetic determinants of primary immunodeficiencies leading to chronic mucocutaneous candidiasis have been reported, and polymorphisms in genes that are known to be involved in anti-Candida host defense are associated with increased susceptibility to systemic infection. These findings have greatly increased our understanding of pathways important for anti-Candida defense in humans, and patterns of prevalence of Candida infections. In addition, these pathways may offer novel therapeutic targets for treatment. This review provides an overview of the current insights in genetic susceptibility to Candida infections and their consequences for the immune response against Candida.

Duke Scholars

Published In

Med Mycol

DOI

EISSN

1460-2709

Publication Date

November 2012

Volume

50

Issue

8

Start / End Page

785 / 794

Location

England

Related Subject Headings

  • Polymorphism, Genetic
  • Microbiology
  • Humans
  • Genetic Predisposition to Disease
  • Candidiasis
  • Candida
  • 3207 Medical microbiology
  • 3202 Clinical sciences
  • 3107 Microbiology
  • 1108 Medical Microbiology
 

Citation

APA
Chicago
ICMJE
MLA
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Plantinga, T. S., Johnson, M. D., Scott, W. K., Joosten, L. A. B., van der Meer, J. W. M., Perfect, J. R., … Netea, M. G. (2012). Human genetic susceptibility to Candida infections. Med Mycol, 50(8), 785–794. https://doi.org/10.3109/13693786.2012.690902
Plantinga, Theo S., Melissa D. Johnson, William K. Scott, Leo A. B. Joosten, Jos W. M. van der Meer, John R. Perfect, Bart Jan Kullberg, and Mihai G. Netea. “Human genetic susceptibility to Candida infections.Med Mycol 50, no. 8 (November 2012): 785–94. https://doi.org/10.3109/13693786.2012.690902.
Plantinga TS, Johnson MD, Scott WK, Joosten LAB, van der Meer JWM, Perfect JR, et al. Human genetic susceptibility to Candida infections. Med Mycol. 2012 Nov;50(8):785–94.
Plantinga, Theo S., et al. “Human genetic susceptibility to Candida infections.Med Mycol, vol. 50, no. 8, Nov. 2012, pp. 785–94. Pubmed, doi:10.3109/13693786.2012.690902.
Plantinga TS, Johnson MD, Scott WK, Joosten LAB, van der Meer JWM, Perfect JR, Kullberg BJ, Netea MG. Human genetic susceptibility to Candida infections. Med Mycol. 2012 Nov;50(8):785–794.
Journal cover image

Published In

Med Mycol

DOI

EISSN

1460-2709

Publication Date

November 2012

Volume

50

Issue

8

Start / End Page

785 / 794

Location

England

Related Subject Headings

  • Polymorphism, Genetic
  • Microbiology
  • Humans
  • Genetic Predisposition to Disease
  • Candidiasis
  • Candida
  • 3207 Medical microbiology
  • 3202 Clinical sciences
  • 3107 Microbiology
  • 1108 Medical Microbiology