3,3'-Disubstituted bipolar biphenyls as inhibitors of nuclear receptor coactivator binding.
Publication
, Journal Article
Weiser, PT; Williams, AB; Chang, C-Y; McDonnell, DP; Hanson, RN
Published in: Bioorg Med Chem Lett
November 1, 2012
A series of bipolar biphenyl compounds was synthesized as proteomimetic analogs of the LXXLL penta-peptide motif responsible for the binding of coactivator proteins to the nuclear hormone receptor coactivator binding domain. These compounds were subjected to multiple in vitro assays to evaluate their effectiveness as competitive binding inhibitors. The results from this initial study indicate that these proteomimetics possess the ability to inhibit this protein-protein interaction.
Duke Scholars
Published In
Bioorg Med Chem Lett
DOI
EISSN
1464-3405
Publication Date
November 1, 2012
Volume
22
Issue
21
Start / End Page
6587 / 6590
Location
England
Related Subject Headings
- Protein Binding
- Nuclear Receptor Coactivators
- Nuclear Receptor Coactivator 2
- Molecular Structure
- Medicinal & Biomolecular Chemistry
- Humans
- Female
- Estrogen Receptor alpha
- Cell Line, Tumor
- Biphenyl Compounds
Citation
APA
Chicago
ICMJE
MLA
NLM
Weiser, P. T., Williams, A. B., Chang, C.-Y., McDonnell, D. P., & Hanson, R. N. (2012). 3,3'-Disubstituted bipolar biphenyls as inhibitors of nuclear receptor coactivator binding. Bioorg Med Chem Lett, 22(21), 6587–6590. https://doi.org/10.1016/j.bmcl.2012.09.007
Weiser, Patrick T., Anna B. Williams, Ching-Yi Chang, Donald P. McDonnell, and Robert N. Hanson. “3,3'-Disubstituted bipolar biphenyls as inhibitors of nuclear receptor coactivator binding.” Bioorg Med Chem Lett 22, no. 21 (November 1, 2012): 6587–90. https://doi.org/10.1016/j.bmcl.2012.09.007.
Weiser PT, Williams AB, Chang C-Y, McDonnell DP, Hanson RN. 3,3'-Disubstituted bipolar biphenyls as inhibitors of nuclear receptor coactivator binding. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6587–90.
Weiser, Patrick T., et al. “3,3'-Disubstituted bipolar biphenyls as inhibitors of nuclear receptor coactivator binding.” Bioorg Med Chem Lett, vol. 22, no. 21, Nov. 2012, pp. 6587–90. Pubmed, doi:10.1016/j.bmcl.2012.09.007.
Weiser PT, Williams AB, Chang C-Y, McDonnell DP, Hanson RN. 3,3'-Disubstituted bipolar biphenyls as inhibitors of nuclear receptor coactivator binding. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6587–6590.
Published In
Bioorg Med Chem Lett
DOI
EISSN
1464-3405
Publication Date
November 1, 2012
Volume
22
Issue
21
Start / End Page
6587 / 6590
Location
England
Related Subject Headings
- Protein Binding
- Nuclear Receptor Coactivators
- Nuclear Receptor Coactivator 2
- Molecular Structure
- Medicinal & Biomolecular Chemistry
- Humans
- Female
- Estrogen Receptor alpha
- Cell Line, Tumor
- Biphenyl Compounds