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Neutron stimulated emission computed tomography of stable isotopes

Publication ,  Journal Article
Floyd, CE; Howell, C; Harrawood, B; Crowell, A; Kapadia, A; Macri, R; Xia, J; Pedroni, R; Bowsher, J; Kiser, M; Tourassi, G; Tornow, W; Walter, R
Published in: Proceedings of SPIE - The International Society for Optical Engineering
July 5, 2004

Here we report on the development of a new molecular imaging technique using inelastic scattering of fast neutrons. Earlier studies demonstrated a significant difference in trace element concentrations between benign and malignant tissue for several cancers including breast, lung, and colon. Unfortunately, the measurement techniques were not compatible with living organisms and this discovery did not translate into diagnostic techniques. Recently we have developed a tomographic approach to measuring the trace element concentrations using neutrons to stimulate characteristic gamma emission from atomic nuclei in the body. Spatial projections of the emitted energy spectra allow tomographic image reconstruction of the elemental concentrations. In preliminary experiments, spectra have been acquired using a 7.5MeV neutron beam incident on several multielement phantoms. These experiments demonstrate our ability to determine the presence of Oxygen, Carbon, Copper, Iron, and Calcium. We desribe the experimental technique and present acquired spectra.

Duke Scholars

Published In

Proceedings of SPIE - The International Society for Optical Engineering

DOI

ISSN

0277-786X

Publication Date

July 5, 2004

Volume

5368

Issue

1

Start / End Page

248 / 254

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering
 

Citation

APA
Chicago
ICMJE
MLA
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Floyd, C. E., Howell, C., Harrawood, B., Crowell, A., Kapadia, A., Macri, R., … Walter, R. (2004). Neutron stimulated emission computed tomography of stable isotopes. Proceedings of SPIE - The International Society for Optical Engineering, 5368(1), 248–254. https://doi.org/10.1117/12.535350
Floyd, C. E., C. Howell, B. Harrawood, A. Crowell, A. Kapadia, R. Macri, J. Xia, et al. “Neutron stimulated emission computed tomography of stable isotopes.” Proceedings of SPIE - The International Society for Optical Engineering 5368, no. 1 (July 5, 2004): 248–54. https://doi.org/10.1117/12.535350.
Floyd CE, Howell C, Harrawood B, Crowell A, Kapadia A, Macri R, et al. Neutron stimulated emission computed tomography of stable isotopes. Proceedings of SPIE - The International Society for Optical Engineering. 2004 Jul 5;5368(1):248–54.
Floyd, C. E., et al. “Neutron stimulated emission computed tomography of stable isotopes.” Proceedings of SPIE - The International Society for Optical Engineering, vol. 5368, no. 1, July 2004, pp. 248–54. Scopus, doi:10.1117/12.535350.
Floyd CE, Howell C, Harrawood B, Crowell A, Kapadia A, Macri R, Xia J, Pedroni R, Bowsher J, Kiser M, Tourassi G, Tornow W, Walter R. Neutron stimulated emission computed tomography of stable isotopes. Proceedings of SPIE - The International Society for Optical Engineering. 2004 Jul 5;5368(1):248–254.

Published In

Proceedings of SPIE - The International Society for Optical Engineering

DOI

ISSN

0277-786X

Publication Date

July 5, 2004

Volume

5368

Issue

1

Start / End Page

248 / 254

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering