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Role of JAK3 in CD40 mediated signaling

Publication ,  Journal Article
Jabara, HH; Buckley, RH; Roberts, JL; Lefranc, G; Loiselet, J; Khalil, G; Geha, RS
Published in: FASEB Journal
March 20, 1998

CD40 is a member of the TNF receptor family and plays an important role in B cell survival, growth, differentiation and isotype switching. Recently, CD40 has been shown to associate with JAK3, a member of the Janus Kinase family which are non-receptor protein kinases that are involved in intracellular signaling mediated by cytokines, interferons, and growth factors. To investigate the role of JAK3 in CD40 mediated signalling, we studied the effect of CD40 stimulation of peripheral blood mononuclear cells (PBMC) obtained from JAK3 deficient patients on proliferation, isotype switching, and upregulation of B cell surface expression of CD23 and ICAM-1. Our studies show that stimulation of PBMC with monoclonal antibody to CD40 in the presence of IL-4 or EL-13, resulted in similar profiles in both patients and normal controls in all the above assays. This suggests that JAK3 is not essential for CD40 mediated B cell proliferation, isotype switching, and upregulation of CD23 and ICAM-1 surface expression.

Duke Scholars

Published In

FASEB Journal

ISSN

0892-6638

Publication Date

March 20, 1998

Volume

12

Issue

5

Related Subject Headings

  • Biochemistry & Molecular Biology
  • 3208 Medical physiology
  • 3101 Biochemistry and cell biology
  • 1116 Medical Physiology
  • 0606 Physiology
  • 0601 Biochemistry and Cell Biology
 

Citation

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Jabara, H. H., Buckley, R. H., Roberts, J. L., Lefranc, G., Loiselet, J., Khalil, G., & Geha, R. S. (1998). Role of JAK3 in CD40 mediated signaling. FASEB Journal, 12(5).
Jabara, H. H., R. H. Buckley, J. L. Roberts, G. Lefranc, J. Loiselet, G. Khalil, and R. S. Geha. “Role of JAK3 in CD40 mediated signaling.” FASEB Journal 12, no. 5 (March 20, 1998).
Jabara HH, Buckley RH, Roberts JL, Lefranc G, Loiselet J, Khalil G, et al. Role of JAK3 in CD40 mediated signaling. FASEB Journal. 1998 Mar 20;12(5).
Jabara, H. H., et al. “Role of JAK3 in CD40 mediated signaling.” FASEB Journal, vol. 12, no. 5, Mar. 1998.
Jabara HH, Buckley RH, Roberts JL, Lefranc G, Loiselet J, Khalil G, Geha RS. Role of JAK3 in CD40 mediated signaling. FASEB Journal. 1998 Mar 20;12(5).

Published In

FASEB Journal

ISSN

0892-6638

Publication Date

March 20, 1998

Volume

12

Issue

5

Related Subject Headings

  • Biochemistry & Molecular Biology
  • 3208 Medical physiology
  • 3101 Biochemistry and cell biology
  • 1116 Medical Physiology
  • 0606 Physiology
  • 0601 Biochemistry and Cell Biology