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Predictors of cardiovascular events in a contemporary population with impaired glucose tolerance: an observational analysis of the Nateglinide and Valsartan in impaired glucose tolerance outcomes research (NAVIGATOR) trial.

Publication ,  Journal Article
Preiss, D; Thomas, LE; Sun, J-L; Haffner, SM; Holman, RR; Standl, E; Leiter, LA; Mazzone, T; Rutten, GE; Tognoni, G; Martinez, FA; Chiang, F-T ...
Published in: BMJ Open
2012

OBJECTIVES: Risk factors for cardiovascular events are well established in general populations and those with diabetes but have been sparsely studied in impaired glucose tolerance (IGT). We sought to identify predictors of (1) a composite cardiovascular outcome (cardiovascular death, non-fatal myocardial infarction and non-fatal stroke) and (2) cardiovascular death, among patients with IGT. DESIGN: We studied participants enrolled in the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research (NAVIGATOR) trial. Predictors of cardiovascular events were identified in observational analyses. SETTING: Clinical trial participants in 40 countries. PARTICIPANTS: 9306 participants with biochemically confirmed IGT at high risk of cardiovascular events participated in NAVIGATOR. PRIMARY AND SECONDARY OUTCOME MEASURES: Cox proportional hazard regression models were constructed using variables (demographic data, medical history, clinical features, biochemical results and ECG findings) recorded at baseline to identify variables associated with and predictive of cardiovascular events. RESULTS: Over 6.4 years, 639 (6.9%) participants experienced a cardiovascular event, and 244 (2.6%) cardiovascular death. While predictors of both outcomes included established risk factors such as existing cardiovascular disease, male gender, older age, current smoking status and higher low-density lipoprotein cholesterol, other variables such as reduced estimated glomerular filtration rate, previous thromboembolic disease, atrial fibrillation, higher urinary albumin/creatinine ratio and chronic obstructive pulmonary disease were also important predictors. Glycaemic measures were not predictive of cardiovascular events. c-Statistics for predicting cardiovascular events and cardiovascular death were 0.74 and 0.82, respectively. This compares with c-statistics for cardiovascular events and cardiovascular death of 0.65 and 0.71, respectively, using the classical Framingham risk factors of age, total cholesterol, high-density lipoprotein cholesterol, systolic blood pressure, treatment for hypertension and smoking status. CONCLUSIONS: The most powerful independent predictors of cardiovascular events in IGT included both established risk factors and other variables excluding measures of glycaemia, allowing effective identification of high-risk individuals.

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Published In

BMJ Open

DOI

EISSN

2044-6055

Publication Date

2012

Volume

2

Issue

6

Location

England

Related Subject Headings

  • 52 Psychology
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 1199 Other Medical and Health Sciences
  • 1117 Public Health and Health Services
  • 1103 Clinical Sciences
 

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Preiss, D., Thomas, L. E., Sun, J.-L., Haffner, S. M., Holman, R. R., Standl, E., … McMurray, J. J. (2012). Predictors of cardiovascular events in a contemporary population with impaired glucose tolerance: an observational analysis of the Nateglinide and Valsartan in impaired glucose tolerance outcomes research (NAVIGATOR) trial. BMJ Open, 2(6). https://doi.org/10.1136/bmjopen-2012-001925
Preiss, David, Laine E. Thomas, Jie-Lena Sun, Steven M. Haffner, Rury R. Holman, Eberhard Standl, Lawrence A. Leiter, et al. “Predictors of cardiovascular events in a contemporary population with impaired glucose tolerance: an observational analysis of the Nateglinide and Valsartan in impaired glucose tolerance outcomes research (NAVIGATOR) trial.BMJ Open 2, no. 6 (2012). https://doi.org/10.1136/bmjopen-2012-001925.
Preiss D, Thomas LE, Sun J-L, Haffner SM, Holman RR, Standl E, Leiter LA, Mazzone T, Rutten GE, Tognoni G, Martinez FA, Chiang F-T, Califf RM, McMurray JJ. Predictors of cardiovascular events in a contemporary population with impaired glucose tolerance: an observational analysis of the Nateglinide and Valsartan in impaired glucose tolerance outcomes research (NAVIGATOR) trial. BMJ Open. 2012;2(6).

Published In

BMJ Open

DOI

EISSN

2044-6055

Publication Date

2012

Volume

2

Issue

6

Location

England

Related Subject Headings

  • 52 Psychology
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 1199 Other Medical and Health Sciences
  • 1117 Public Health and Health Services
  • 1103 Clinical Sciences