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Etiological and clinical features of childhood psychotic symptoms: results from a birth cohort.

Publication ,  Journal Article
Polanczyk, G; Moffitt, TE; Arseneault, L; Cannon, M; Ambler, A; Keefe, RSE; Houts, R; Odgers, CL; Caspi, A
Published in: Arch Gen Psychiatry
April 2010

CONTEXT: It has been reported that childhood psychotic symptoms are common in the general population and may signal neurodevelopmental processes that lead to schizophrenia. However, it is not clear whether these symptoms are associated with the same extensive risk factors established for adult schizophrenia. OBJECTIVE: To examine the construct validity of children's self-reported psychotic symptoms by testing whether these symptoms share the risk factors and clinical features of adult schizophrenia. DESIGN: Prospective, longitudinal cohort study of a nationally representative birth cohort in Great Britain. PARTICIPANTS: A total of 2232 twelve-year-old children followed up since age 5 years (retention, 96%). Main Outcome Measure Children's self-reported hallucinations and delusions. RESULTS: Children's psychotic symptoms are familial and heritable and are associated with social risk factors (eg, urbanicity); cognitive impairments at age 5; home-rearing risk factors (eg, maternal expressed emotion); behavioral, emotional, and educational problems at age 5; and comorbid conditions, including self-harm. CONCLUSIONS: The results provide a comprehensive picture of the construct validity of children's self-reported psychotic symptoms. For researchers, the findings indicate that children who have psychotic symptoms can be recruited for neuroscience research to determine the pathogenesis of schizophrenia. For clinicians, the findings indicate that psychotic symptoms in childhood are often a marker of an impaired developmental process and should be actively assessed.

Duke Scholars

Published In

Arch Gen Psychiatry

DOI

EISSN

1538-3636

Publication Date

April 2010

Volume

67

Issue

4

Start / End Page

328 / 338

Location

United States

Related Subject Headings

  • United Kingdom
  • Twins, Monozygotic
  • Twins, Dizygotic
  • Self-Injurious Behavior
  • Schizophrenic Psychology
  • Schizophrenia
  • Risk Factors
  • Psychotic Disorders
  • Psychiatry
  • Psychiatric Status Rating Scales
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Polanczyk, G., Moffitt, T. E., Arseneault, L., Cannon, M., Ambler, A., Keefe, R. S. E., … Caspi, A. (2010). Etiological and clinical features of childhood psychotic symptoms: results from a birth cohort. Arch Gen Psychiatry, 67(4), 328–338. https://doi.org/10.1001/archgenpsychiatry.2010.14
Polanczyk, Guilherme, Terrie E. Moffitt, Louise Arseneault, Mary Cannon, Antony Ambler, Richard S. E. Keefe, Renate Houts, Candice L. Odgers, and Avshalom Caspi. “Etiological and clinical features of childhood psychotic symptoms: results from a birth cohort.Arch Gen Psychiatry 67, no. 4 (April 2010): 328–38. https://doi.org/10.1001/archgenpsychiatry.2010.14.
Polanczyk G, Moffitt TE, Arseneault L, Cannon M, Ambler A, Keefe RSE, et al. Etiological and clinical features of childhood psychotic symptoms: results from a birth cohort. Arch Gen Psychiatry. 2010 Apr;67(4):328–38.
Polanczyk, Guilherme, et al. “Etiological and clinical features of childhood psychotic symptoms: results from a birth cohort.Arch Gen Psychiatry, vol. 67, no. 4, Apr. 2010, pp. 328–38. Pubmed, doi:10.1001/archgenpsychiatry.2010.14.
Polanczyk G, Moffitt TE, Arseneault L, Cannon M, Ambler A, Keefe RSE, Houts R, Odgers CL, Caspi A. Etiological and clinical features of childhood psychotic symptoms: results from a birth cohort. Arch Gen Psychiatry. 2010 Apr;67(4):328–338.

Published In

Arch Gen Psychiatry

DOI

EISSN

1538-3636

Publication Date

April 2010

Volume

67

Issue

4

Start / End Page

328 / 338

Location

United States

Related Subject Headings

  • United Kingdom
  • Twins, Monozygotic
  • Twins, Dizygotic
  • Self-Injurious Behavior
  • Schizophrenic Psychology
  • Schizophrenia
  • Risk Factors
  • Psychotic Disorders
  • Psychiatry
  • Psychiatric Status Rating Scales