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Mechanisms of the antioxidant effects of nitric oxide.

Publication ,  Journal Article
Wink, DA; Miranda, KM; Espey, MG; Pluta, RM; Hewett, SJ; Colton, C; Vitek, M; Feelisch, M; Grisham, MB
Published in: Antioxid Redox Signal
April 2001

The Janus face of nitric oxide (NO) has prompted a debate as to whether NO plays a deleterious or protective role in tissue injury. There are a number of reactive nitrogen oxide species, such as N2O3 and ONOO-, that can alter critical cellular components under high local concentrations of NO. However, NO can also abate the oxidation chemistry mediated by reactive oxygen species such as H2O2 and O2- that occurs at physiological levels of NO. In addition to the antioxidant chemistry, NO protects against cell death mediated by H2O2, alkylhydroperoxides, and xanthine oxidase. The attenuation of metal/peroxide oxidative chemistry, as well as lipid peroxidation, appears to be the major chemical mechanisms by which NO may limit oxidative injury to mammalian cells. In addition to these chemical and biochemical properties, NO can modulate cellular and physiological processes to limit oxidative injury, limiting processes such as leukocyte adhesion. This review will address these aspects of the chemical biology of this multifaceted free radical and explore the beneficial effect of NO against oxidative stress.

Duke Scholars

Published In

Antioxid Redox Signal

DOI

ISSN

1523-0864

Publication Date

April 2001

Volume

3

Issue

2

Start / End Page

203 / 213

Location

United States

Related Subject Headings

  • Reactive Oxygen Species
  • Oxidative Stress
  • Nitric Oxide
  • Lipid Peroxidation
  • Humans
  • Free Radicals
  • Cytotoxicity, Immunologic
  • Biochemistry & Molecular Biology
  • Antioxidants
  • Animals
 

Citation

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Wink, D. A., Miranda, K. M., Espey, M. G., Pluta, R. M., Hewett, S. J., Colton, C., … Grisham, M. B. (2001). Mechanisms of the antioxidant effects of nitric oxide. Antioxid Redox Signal, 3(2), 203–213. https://doi.org/10.1089/152308601300185179
Wink, D. A., K. M. Miranda, M. G. Espey, R. M. Pluta, S. J. Hewett, C. Colton, M. Vitek, M. Feelisch, and M. B. Grisham. “Mechanisms of the antioxidant effects of nitric oxide.Antioxid Redox Signal 3, no. 2 (April 2001): 203–13. https://doi.org/10.1089/152308601300185179.
Wink DA, Miranda KM, Espey MG, Pluta RM, Hewett SJ, Colton C, et al. Mechanisms of the antioxidant effects of nitric oxide. Antioxid Redox Signal. 2001 Apr;3(2):203–13.
Wink, D. A., et al. “Mechanisms of the antioxidant effects of nitric oxide.Antioxid Redox Signal, vol. 3, no. 2, Apr. 2001, pp. 203–13. Pubmed, doi:10.1089/152308601300185179.
Wink DA, Miranda KM, Espey MG, Pluta RM, Hewett SJ, Colton C, Vitek M, Feelisch M, Grisham MB. Mechanisms of the antioxidant effects of nitric oxide. Antioxid Redox Signal. 2001 Apr;3(2):203–213.
Journal cover image

Published In

Antioxid Redox Signal

DOI

ISSN

1523-0864

Publication Date

April 2001

Volume

3

Issue

2

Start / End Page

203 / 213

Location

United States

Related Subject Headings

  • Reactive Oxygen Species
  • Oxidative Stress
  • Nitric Oxide
  • Lipid Peroxidation
  • Humans
  • Free Radicals
  • Cytotoxicity, Immunologic
  • Biochemistry & Molecular Biology
  • Antioxidants
  • Animals