S-nitrosylation of Ras in breast cancer.
Publication
, Journal Article
Marshall, HE; Foster, MW
Published in: Breast Cancer Res
November 12, 2012
Elevated expression of nitric oxide synthase 2 has been recently shown to correlate with poor survival in estrogen receptor-negative breast cancer. In an article in Breast Cancer Research, Switzer and colleagues identify the transcription factor Ets-1 as a critical mediator of nitric oxide-dependent oncogenic gene expression in basal-like breast cancer. This pathway is driven by S-nitrosylation of wild-type Ras, which leads to mitogen-activated protein kinase-dependent phosphorylation and activation of Ets-1. These results establish a new role for S-nitrosylation in mediating an aggressive breast cancer phenotype.
Duke Scholars
Published In
Breast Cancer Res
DOI
EISSN
1465-542X
Publication Date
November 12, 2012
Volume
14
Issue
6
Start / End Page
113
Location
England
Related Subject Headings
- Signal Transduction
- Receptors, Estrogen
- Proto-Oncogene Protein c-ets-1
- Oncology & Carcinogenesis
- Nitric Oxide
- Humans
- Female
- Breast Neoplasms
- 3211 Oncology and carcinogenesis
- 1112 Oncology and Carcinogenesis
Citation
APA
Chicago
ICMJE
MLA
NLM
Marshall, H. E., & Foster, M. W. (2012). S-nitrosylation of Ras in breast cancer. Breast Cancer Res, 14(6), 113. https://doi.org/10.1186/bcr3331
Marshall, Harvey E., and Matthew W. Foster. “S-nitrosylation of Ras in breast cancer.” Breast Cancer Res 14, no. 6 (November 12, 2012): 113. https://doi.org/10.1186/bcr3331.
Marshall HE, Foster MW. S-nitrosylation of Ras in breast cancer. Breast Cancer Res. 2012 Nov 12;14(6):113.
Marshall, Harvey E., and Matthew W. Foster. “S-nitrosylation of Ras in breast cancer.” Breast Cancer Res, vol. 14, no. 6, Nov. 2012, p. 113. Pubmed, doi:10.1186/bcr3331.
Marshall HE, Foster MW. S-nitrosylation of Ras in breast cancer. Breast Cancer Res. 2012 Nov 12;14(6):113.
Published In
Breast Cancer Res
DOI
EISSN
1465-542X
Publication Date
November 12, 2012
Volume
14
Issue
6
Start / End Page
113
Location
England
Related Subject Headings
- Signal Transduction
- Receptors, Estrogen
- Proto-Oncogene Protein c-ets-1
- Oncology & Carcinogenesis
- Nitric Oxide
- Humans
- Female
- Breast Neoplasms
- 3211 Oncology and carcinogenesis
- 1112 Oncology and Carcinogenesis