Scholars@Duke publication: Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies.

Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies.

Publication , Journal Article

Assimes, TL; Hólm, H; Kathiresan, S; Reilly, MP; Thorleifsson, G; Voight, BF; Erdmann, J; Willenborg, C; Vaidya, D; Xie, C; Patterson, CC ...

Published in: J Am Coll Cardiol

November 2, 2010

Published version (DOI) Link to item

OBJECTIVES: We sought to replicate the association between the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism (rs20455), and clinical coronary artery disease (CAD). BACKGROUND: Recent prospective studies suggest that carriers of the 719Arg allele in KIF6 are at increased risk of clinical CAD compared with noncarriers. METHODS: The KIF6 Trp719Arg polymorphism (rs20455) was genotyped in 19 case-control studies of nonfatal CAD either as part of a genome-wide association study or in a formal attempt to replicate the initial positive reports. RESULTS: A total of 17,000 cases and 39,369 controls of European descent as well as a modest number of South Asians, African Americans, Hispanics, East Asians, and admixed cases and controls were successfully genotyped. None of the 19 studies demonstrated an increased risk of CAD in carriers of the 719Arg allele compared with noncarriers. Regression analyses and fixed-effects meta-analyses ruled out with high degree of confidence an increase of ≥2% in the risk of CAD among European 719Arg carriers. We also observed no increase in the risk of CAD among 719Arg carriers in the subset of Europeans with early-onset disease (younger than 50 years of age for men and younger than 60 years of age for women) compared with similarly aged controls as well as all non-European subgroups. CONCLUSIONS: The KIF6 Trp719Arg polymorphism was not associated with the risk of clinical CAD in this large replication study.

Duke Scholars

Author Svati Hasmukh Shah Medicine, Cardiology

Author Christopher Bull Granger Medicine, Cardiology

Altmetric Attention Stats

Dimensions Citation Stats

Published In

J Am Coll Cardiol

DOI

10.1016/j.jacc.2010.06.022

EISSN

1558-3597

Publication Date

November 2, 2010

Volume

Issue

Start / End Page

1552 / 1563

Location

United States

Related Subject Headings

Tryptophan
Risk Factors
Polymorphism, Single Nucleotide
Middle Aged
Male
Kinesins
Internationality
Humans
Genome-Wide Association Study
Female

Citation

APA

Chicago

ICMJE

MLA

NLM

Assimes, T. L., Hólm, H., Kathiresan, S., Reilly, M. P., Thorleifsson, G., Voight, B. F., … Quertermous, T. (2010). Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. J Am Coll Cardiol, 56(19), 1552–1563. https://doi.org/10.1016/j.jacc.2010.06.022

Assimes, Themistocles L., Hilma Hólm, Sekar Kathiresan, Muredach P. Reilly, Gudmar Thorleifsson, Benjamin F. Voight, Jeanette Erdmann, et al. “Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies.” J Am Coll Cardiol 56, no. 19 (November 2, 2010): 1552–63. https://doi.org/10.1016/j.jacc.2010.06.022.

Assimes TL, Hólm H, Kathiresan S, Reilly MP, Thorleifsson G, Voight BF, et al. Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. J Am Coll Cardiol. 2010 Nov 2;56(19):1552–63.

Assimes, Themistocles L., et al. “Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies.” J Am Coll Cardiol, vol. 56, no. 19, Nov. 2010, pp. 1552–63. Pubmed, doi:10.1016/j.jacc.2010.06.022.

Assimes TL, Hólm H, Kathiresan S, Reilly MP, Thorleifsson G, Voight BF, Erdmann J, Willenborg C, Vaidya D, Xie C, Patterson CC, Morgan TM, Burnett MS, Li M, Hlatky MA, Knowles JW, Thompson JR, Absher D, Iribarren C, Go A, Fortmann SP, Sidney S, Risch N, Tang H, Myers RM, Berger K, Stoll M, Shah SH, Thorgeirsson G, Andersen K, Havulinna AS, Herrera JE, Faraday N, Kim Y, Kral BG, Mathias RA, Ruczinski I, Suktitipat B, Wilson AF, Yanek LR, Becker LC, Linsel-Nitschke P, Lieb W, König IR, Hengstenberg C, Fischer M, Stark K, Reinhard W, Winogradow J, Grassl M, Grosshennig A, Preuss M, Schreiber S, Wichmann H-E, Meisinger C, Yee J, Friedlander Y, Do R, Meigs JB, Williams G, Nathan DM, MacRae CA, Qu L, Wilensky RL, Matthai WH, Qasim AN, Hakonarson H, Pichard AD, Kent KM, Satler L, Lindsay JM, Waksman R, Knouff CW, Waterworth DM, Walker MC, Mooser VE, Marrugat J, Lucas G, Subirana I, Sala J, Ramos R, Martinelli N, Olivieri O, Trabetti E, Malerba G, Pignatti PF, Guiducci C, Mirel D, Parkin M, Hirschhorn JN, Asselta R, Duga S, Musunuru K, Daly MJ, Purcell S, Eifert S, Braund PS, Wright BJ, Balmforth AJ, Ball SG, Myocardial Infarction Genetics Consortium, Wellcome Trust Case Control Consortium, Cardiogenics, Ouwehand WH, Deloukas P, Scholz M, Cambien F, Huge A, Scheffold T, Salomaa V, Girelli D, Granger CB, Peltonen L, McKeown PP, Altshuler D, Melander O, Devaney JM, Epstein SE, Rader DJ, Elosua R, Engert JC, Anand SS, Hall AS, Ziegler A, O’Donnell CJ, Spertus JA, Siscovick D, Schwartz SM, Becker D, Thorsteinsdottir U, Stefansson K, Schunkert H, Samani NJ, Quertermous T. Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. J Am Coll Cardiol. 2010 Nov 2;56(19):1552–1563.

Published In

J Am Coll Cardiol

DOI

10.1016/j.jacc.2010.06.022

EISSN

1558-3597

Publication Date

November 2, 2010

Volume

Issue

Start / End Page

1552 / 1563

Location

United States

Related Subject Headings

Tryptophan
Risk Factors
Polymorphism, Single Nucleotide
Middle Aged
Male
Kinesins
Internationality
Humans
Genome-Wide Association Study
Female